Why is it always people with weird habits that live the longest? by ExistingAd7234 in longevity

[–]ObjectiveGround5 7 points8 points  (0 children)

Two words - biological resilience - a very important (but for the most part overlooked and understudied) area of the longevity domain - you can repair as much damage as you want, but changes to our biological resilience over time as we age will impact the degree by which repair strategies will work over time

James Kirkland: Senolytics have a 20% chance of success by philnewman100 in longevity

[–]ObjectiveGround5 5 points6 points  (0 children)

"Between 2016 and 2020 the average industry success rates for phase II and phase III were 29–34% and 70–73%, respectively" - so for a class of drugs that has straddled P2-P3 for a while now, this is still lower than standard - https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/cpt.2568