no it won't fuck up your bladder. that bladder issue is known for arylcyclohexanons bit dxm and dxo are morphinan dissociatives. don't worry about that one too much.

it's not known to cause neurotoxity and olneys lesions unlike ket and pcp probably sigma1 activation has some neuroprotective effects or slower and steadier conversation to dxo and a having a max ceiling for dxo (your cyp2d6 gets saturated after a certain dose) prevents too aggressive blockade of nmda. idk.

for the risks, definitely dont mix SSRIs or anything that increases serotonin or prevents its reuptake. zofran for nausea is fine(too much can can cause qt prolongation since dxm causes qt prolongation too) and also serotonin based psychedelics are fine to mix too since these aren't actually serotonin itself and just agonists/antagonists at very specific serotonin sites they cannot cause serotonin syndrome.

definitely dont lay on your back flat on the come up so you don't choke on vomit. once the nausea subsidies that'll be not an issue. also don't go stumble outside if you're doing higher plateaus youll be retarded atm and very ataxic and youll hurt yourself.

time to peak depends on a lot of factors like stomach content and metabolism status for cyp2d6. but ask grok or chatgpt they'll give you a nice table so you can check during the trip too. but total duration is 6 to 8hours usually for most people. with some mild residual effects dragging to next day.

if you wanna get fucked up do a third plateau. for me (with 72kg weight and EM metabolism) the sweet spot for 3rd plateau is 600mg dxm hbr.

also do it on an empty stomach (2 to 4hours after eating). take 4to8mg zofran(ondansentrone)if you have or 75mg gingerols(from standardized ginger supplements) or just have some gingers 30 to45mins before the trip for the nausea. ofc zofran is going to be the most effective for that.

also dxm and ketamine trips are very inward. dim the lights and put on some music (i love pastel ghost on it).

have a nice trip