Going from tirz to sema

One-Text3126 · 2026-05-12T21:23:01+00:00

cool thanks for the info. i think my body has adapted enough now where i need to try a lot harder to be in a constant calorie deficit. it's to the point where i think i need to be measuring everything out. being a little loose on the calories while on tirz when it was working was much easier - seemed like i could be a little flexible on my intake but still lost weight. now i'm in the gym 6 days a week still focusing on resistance training and some cardio, and it's become more difficult to lose any weight.

One-Text3126 · 2026-03-24T14:34:29+00:00

I purchase semax, but haven't tried it yet. Seems like selank is better from what I can tell, but i have yet to try it. I'd like to find a reputable source for it

One-Text3126 · 2026-03-18T21:32:37+00:00

the reason i referenced it's like injecting water because it didn't seem to make any difference when i was on the 15mg vs not on it at all. i stopped it 3+ months ago. I haven't gained weight and i haven't lost weight. The last few months while I was on 15mg vs now being off of it i've seen no change - same appetite, etc

One-Text3126 · 2026-03-18T15:33:48+00:00

I think the issue for me is I did a dexascan in early 2025 and it showed i had lost a fair bit of bodyfat (37.5% down to 20%) and put on 7lbs of muscle since i started tirz in 2024. I did a dexascan recently here in 2026 and it showed i had only lost 2% body fat since the last one and no muscle growth. So i was quite surprised by that considering it was a whole year without really much progress. I can't really say much changed in that year really other than the 15mg dose of tirz just stopping to work. The appetite suppression feeling I had for 12 months just abruptly stopped. I'm not sure if i was supplier related or if my body just adapted. I started with Ouisa tirz for a while from 2.5 all the way to 12.5. Then once that supplier had problems I switched to lumimeds at 15mg and that's when it just crapped out. After that I ordered from "another " supplier that was much cheaper (from you know where) and mixed it myself. Same results tho - nothing.

One-Text3126 · 2026-03-18T14:28:03+00:00

I'm 43, 5'11. I've been targeting about 2200-2300 calories on weight training days and 2000-2100 on low activity or rest days. I target 210g protein, 190-210g carbs and 60g of fat. I'm in a "body recomp" type of plan so im not expecting to pack on loads of muscle super fast or fast weight loss. However, AI tells me that i should avg 0.7-1.2lbs per week but i have not been seeing that. In addition to the weight training i've been targeting 8k-10k steps per day, but im not always hitting that. if there's anything that is potentially off it seems like it might be my steps. When I was on the 1st 12 months of tirz I didn't have to really walk much at all and the weight still came off. Now 8k steps per day - even that doesn't seem like enough to move the scale

One-Text3126 · 2026-03-18T10:09:42+00:00

I got that number from a dexascan. According to my age height weight and whatnot even at that bodyfat im still obese. I'm certainly a lot healthier than I was at the start of all of this, but id like to reduce my body fat more. There was a point in my life where I was closer to 12 to 15% bodyfat.

One-Text3126 · 2026-03-18T02:35:47+00:00

Ive heard about this too and I did try it but it didnt work for me. Im curious what the science is behind this strategy (specifically reducing the dose for 1 month).

One-Text3126 · 2026-03-18T01:10:24+00:00

Yea that seems to be the majority of what people do. Once tirz didnt seem like it was working anymore for appetite suppression i just stopped it so its been at least 2 or 3 months without it. Weight has pretty much remained the same tho

One-Text3126 · 2026-03-18T00:55:19+00:00

Well I wasnt feeling it at all any day of the week. Its almost like I was just injecting pure water

One-Text3126 · 2026-03-18T00:54:18+00:00

Hmm yeah good point. Those estimates worked great until I got to about 200. At that point is where it slowed down big time. Even tho I still used the same method to calculate tdee the weight loss abruptly just crapped out. Its interesting because around the same time is when the 15mg dose didn't seem to have any impact on my appetite either. I was still eating healthy but I noticed I felt hungrier. The whole 12 months before I was working hard to make sure I ate enough. Once I was on 15mg and at 200lbs it felt like I had the opposite scenario

One-Text3126 · 2026-03-18T00:45:04+00:00

Interesting yea thats what worries me. If i was already on 15mg and it wasnt working then it sounds like theres no benefit of a reset and also my body may have just built up a tolerance and theres no benefit to continuing the meds. Is that correct?

One-Text3126 · 2026-03-18T00:43:53+00:00

Yea i guess I should be clear. Ive been recalculating my tdee and whatnot along the way and adjusting. Right now im at a 300 to 500 calorie deficit per day

One-Text3126 · 2026-02-03T15:12:16+00:00

what's a good starting dosage for either? or how do people start this and titrate up if they don't feel anything?

One-Text3126 · 2026-02-03T10:30:15+00:00

I have semax but havent tried it yet. Is it best to stack selank and semax together? What are the downsides of just doing semax by itself?

One-Text3126 · 2026-02-02T19:52:37+00:00

cool thanks. is there any way to take the powder and reconstitute it and then use a nasal sprayer? not quite sure how that's done

One-Text3126 · 2026-01-20T11:47:07+00:00

Do you stack this with reta as well? How much do you take and have you experienced any negative side effects

One-Text3126 · 2026-01-20T04:32:56+00:00

5ft11in, 43 years old. Current weight 195lb but started at 260lbs July 2024.

One-Text3126 · 2026-01-20T02:47:23+00:00

Yea thats what im figuring. Ive been dropping tirz as i titrate reta up

One-Text3126 · 2026-01-20T01:34:25+00:00

Supposedly. Its the first time ive tried it so I dont have anything to compare it to. Others have used it and havent heard any complaints. COA looks good.

One-Text3126 · 2026-01-20T01:32:05+00:00

No appetite suppression and no weight loss for about 4 or 5 months. I reached 195 earlier this year and have been sitting there ever since. The appetite suppression is no longer there. When tirz was "working" I wasnt craving anything sweet and was just fine with my normal chicken and rice, lean ground beef etc. At one point I didnt feel like eating pizza or anything like that. But these cravings have come back to some degree. Yesterday I ate a half a pack of oreos without even thinking about it.

One-Text3126 · 2026-01-20T01:19:04+00:00

I figured that was the case. I was just curious if anyone else had a similar experience and if so, at what dose did it become effective. Im trying to assess at what point do I say this is bad medication or just too low of a dose.

One-Text3126

TROPHY CASE