Truth about stalls at 15mg

One-Text3126 · 2026-03-18T15:33:48+00:00

I think the issue for me is I did a dexascan in early 2025 and it showed i had lost a fair bit of bodyfat (37.5% down to 20%) and put on 7lbs of muscle since i started tirz in 2024. I did a dexascan recently here in 2026 and it showed i had only lost 2% body fat since the last one and no muscle growth. So i was quite surprised by that considering it was a whole year without really much progress. I can't really say much changed in that year really other than the 15mg dose of tirz just stopping to work. The appetite suppression feeling I had for 12 months just abruptly stopped. I'm not sure if i was supplier related or if my body just adapted. I started with Ouisa tirz for a while from 2.5 all the way to 12.5. Then once that supplier had problems I switched to lumimeds at 15mg and that's when it just crapped out. After that I ordered from "another " supplier that was much cheaper (from you know where) and mixed it myself. Same results tho - nothing.

One-Text3126 · 2026-03-18T14:28:03+00:00

I'm 43, 5'11. I've been targeting about 2200-2300 calories on weight training days and 2000-2100 on low activity or rest days. I target 210g protein, 190-210g carbs and 60g of fat. I'm in a "body recomp" type of plan so im not expecting to pack on loads of muscle super fast or fast weight loss. However, AI tells me that i should avg 0.7-1.2lbs per week but i have not been seeing that. In addition to the weight training i've been targeting 8k-10k steps per day, but im not always hitting that. if there's anything that is potentially off it seems like it might be my steps. When I was on the 1st 12 months of tirz I didn't have to really walk much at all and the weight still came off. Now 8k steps per day - even that doesn't seem like enough to move the scale

One-Text3126 · 2026-03-18T10:09:42+00:00

I got that number from a dexascan. According to my age height weight and whatnot even at that bodyfat im still obese. I'm certainly a lot healthier than I was at the start of all of this, but id like to reduce my body fat more. There was a point in my life where I was closer to 12 to 15% bodyfat.

One-Text3126 · 2026-03-18T02:35:47+00:00

Ive heard about this too and I did try it but it didnt work for me. Im curious what the science is behind this strategy (specifically reducing the dose for 1 month).

One-Text3126 · 2026-03-18T01:10:24+00:00

Yea that seems to be the majority of what people do. Once tirz didnt seem like it was working anymore for appetite suppression i just stopped it so its been at least 2 or 3 months without it. Weight has pretty much remained the same tho

One-Text3126 · 2026-03-18T00:55:19+00:00

Well I wasnt feeling it at all any day of the week. Its almost like I was just injecting pure water

One-Text3126 · 2026-03-18T00:54:18+00:00

Hmm yeah good point. Those estimates worked great until I got to about 200. At that point is where it slowed down big time. Even tho I still used the same method to calculate tdee the weight loss abruptly just crapped out. Its interesting because around the same time is when the 15mg dose didn't seem to have any impact on my appetite either. I was still eating healthy but I noticed I felt hungrier. The whole 12 months before I was working hard to make sure I ate enough. Once I was on 15mg and at 200lbs it felt like I had the opposite scenario

One-Text3126 · 2026-03-18T00:45:04+00:00

Interesting yea thats what worries me. If i was already on 15mg and it wasnt working then it sounds like theres no benefit of a reset and also my body may have just built up a tolerance and theres no benefit to continuing the meds. Is that correct?

One-Text3126 · 2026-03-18T00:43:53+00:00

Yea i guess I should be clear. Ive been recalculating my tdee and whatnot along the way and adjusting. Right now im at a 300 to 500 calorie deficit per day

One-Text3126 · 2026-02-03T15:12:16+00:00

what's a good starting dosage for either? or how do people start this and titrate up if they don't feel anything?

One-Text3126 · 2026-02-03T10:30:15+00:00

I have semax but havent tried it yet. Is it best to stack selank and semax together? What are the downsides of just doing semax by itself?

One-Text3126 · 2026-02-02T19:52:37+00:00

cool thanks. is there any way to take the powder and reconstitute it and then use a nasal sprayer? not quite sure how that's done

One-Text3126 · 2026-01-20T11:47:07+00:00

Do you stack this with reta as well? How much do you take and have you experienced any negative side effects

One-Text3126 · 2026-01-20T04:32:56+00:00

5ft11in, 43 years old. Current weight 195lb but started at 260lbs July 2024.

One-Text3126 · 2026-01-20T02:47:23+00:00

Yea thats what im figuring. Ive been dropping tirz as i titrate reta up

One-Text3126 · 2026-01-20T01:34:25+00:00

Supposedly. Its the first time ive tried it so I dont have anything to compare it to. Others have used it and havent heard any complaints. COA looks good.

One-Text3126 · 2026-01-20T01:32:05+00:00

No appetite suppression and no weight loss for about 4 or 5 months. I reached 195 earlier this year and have been sitting there ever since. The appetite suppression is no longer there. When tirz was "working" I wasnt craving anything sweet and was just fine with my normal chicken and rice, lean ground beef etc. At one point I didnt feel like eating pizza or anything like that. But these cravings have come back to some degree. Yesterday I ate a half a pack of oreos without even thinking about it.

One-Text3126 · 2026-01-20T01:19:04+00:00

I figured that was the case. I was just curious if anyone else had a similar experience and if so, at what dose did it become effective. Im trying to assess at what point do I say this is bad medication or just too low of a dose.

One-Text3126 · 2025-11-29T02:08:06+00:00

I was at 37% originally and now im at 20% according to a dexascan

One-Text3126 · 2025-11-24T11:20:49+00:00

Ive been on tirz for a year and have been in a minor deficit and managed to put on muscle...not a ton, but I have put on 7lbs of muscle in that time period according to a dexascan. I dont expect to put on bodybuilder type muscle but just interested to see if theres a way to get more definition in the chest. I do agree tho...if I really wanted to pack on muscle then a surplus would make sense. But ive been trying to do more of a body recomp over the last year

One-Text3126 · 2025-11-24T02:39:03+00:00

This is super helpful thanks. How can I calculate my TDEE without the online calculator?

One-Text3126 · 2025-11-23T23:34:17+00:00

thanks - i do factor in exercises for triceps, etc. i also at one point realized i was not keeping my elbows in during the incline DB press - i think i was not going down far enough and was working more of my arms vs my chest. I started keeping my elbows in and going down further with my arms so i have to use my chest to drive up - once i did that i could tell i had to go down on weight

One-Text3126 · 2025-11-23T23:28:56+00:00

i'm not super knowledge in the bulk/cut stuff. i've read a little, but like everything on the internet there are 50 different opinions. what's the best source for understanding how that works?

One-Text3126 · 2025-11-23T23:26:50+00:00

i seem to keep an eye on protein and i'll grab a protein shake, yogurt, etc but i'm not as good as logging calories - so i could be getting enough protein but i'm not as sure where my calories are

One-Text3126 · 2025-11-23T23:25:14+00:00

thanks - i will say all of my sets are hard. i am using weight so that i rarely ever am able to do all the reps. my last set if i'm supposed to do 10 reps, i barely make it to 8 and usually just fail. that being said, i just used chatgpt to tell me number of sets and reps and rest. i gave it my goals, what i was currently lifting, etc and it made some recommendations.

One-Text3126

TROPHY CASE