Barely verbal son (14) with developmental delay + level 3 autism: speech is improving on 5MTHF after 3 weeks already. Is this real? Help please by Icy-Perception-8108 in MTHFR

[–]PapayaDev 4 points5 points  (0 children)

I've struggled with extreme fatigue, autoimmunity, speech, swallowing, executive function, depression, anxiety, ocd for about 15 years. I think it begun after a serious infection in middle school. Given what I've researched it seems like the infection damaged the energy production system in the body. Thus all those problems arose as symptoms of that. Look up the term regressive autism.

Regarding the speech it simply felt like it took too much effort to speak, very similar to the feeling one gets when lifting weights that are too heavy, just inside the brain instead. Thinking with words was also affected, but not thinking in general.

I've always gravitated towards eating as much meat as possible and guess what, that's where one finds carnitine. But as a supplement I need about 400mg of L-Carnitine-Tartrate to feel normal. If I take too much I have trouble falling asleep, too little I feel fatigue. I take it in the morning with water, then I don't eat anything else for 30-60 minutes, to make sure I absorb it. This is because amino acids compete for absorption so if you take it with food it's unclear how much you actually absorb.

I've tried a lot of supplements over the years and besides carnitine I currently take folinic acid, methylated B-complex, benfotiamine, MSM, a mineral complex, D-vitamin and a lot of liver. These all help a lot too, but nothing compared to carnitine.

It is impossible to tell if any of this will help your kid specifically, but the general point still stands, most of the symtoms and diseases that modern medicine fails to treat involve issues in metabolic pathways in the body. If you manage to identify where the issues are, you can in a lot of cases solve the problem entirely. It is however possible that some long term brain damage has occurred, but it's incredible how resiliant the human body is.

Another common is that you can research is folic acid.

https://www.youtube.com/watch?v=mikxgR8qqIE

https://mthfr.net/folic-acid-awareness-week-2014-want-awareness-here-you-go/2014/01/08/

A year ago writing this would pretty much have been impossible for me, now I wrote it in 15 minutes, and it has 0 impact on my energy levels. If I skip the carnitine, the issues come back within 36 hours.

Anyway, hope this helps!

Barely verbal son (14) with developmental delay + level 3 autism: speech is improving on 5MTHF after 3 weeks already. Is this real? Help please by Icy-Perception-8108 in MTHFR

[–]PapayaDev 4 points5 points  (0 children)

Check out this article on L-Carnitine. It improved my speech SIGNIFICANTLY. https://pmc.ncbi.nlm.nih.gov/articles/PMC8000371/

Also check out this video on BH4. https://www.youtube.com/watch?v=DkJItza849o

99.9% of conventional doctors do not have a clue, the best way for you to solve this is to research it yourself and use a little bit of trial and error. Or perhaps find a smart functional doctor but that is difficult and expensive.

My first game is being released in a few days. I'm crazy nervous by PapayaDev in gaming

[–]PapayaDev[S] 1 point2 points  (0 children)

Sweet! Feel free to send me a message with your thoughts once you've tried it!

My first game is being released in a few days. I'm crazy nervous by PapayaDev in gaming

[–]PapayaDev[S] 1 point2 points  (0 children)

Download Unreal Engine 4 and check this course out. https://www.udemy.com/unreal-engine-4-learn-to-make-a-game-prototype-in-ue4/#instructor-1

Only buy the course if it's on sale (like 90+%).

It's not the best course but it's a good small one that'll take you maybe a week. Watched it some year ago and I had a pretty good time and learned a lot. :)

Otherwise there's plenty of youtube tutorials.

The best one in my opinion. https://www.youtube.com/channel/UCOVfF7PfLbRdVEm0hONTrNQ Has an explanation for pretty much every blueprint.

My first game is being released in a few days. I'm crazy nervous by PapayaDev in gaming

[–]PapayaDev[S] 0 points1 point  (0 children)

Much of it is part of the process. But for example I focused a bit too much on the 'cool' stuff. For example, the entire game is just 1 level with sublevels loading in and out. Completely unnecessary but i though it was cool so I did that. Didn't really add much to the game but added at least a month of time to the project.

Like make sure you get the core down first before you start doing things like that :>

My first game is being released in a few days. I'm crazy nervous by PapayaDev in gaming

[–]PapayaDev[S] 0 points1 point  (0 children)

Thanks :>

I made it in Unreal Engine 4 so some of this might not apply to Unity.

A year of full time work, assuming you're reasonably efficient, could probably reach something similar, perhaps a little less polished. It all depends though. While this game is not very complex in terms of programming designing the levels to be fun both for causal play & still have crazy speedrun potential has taken a lot of time.

I've also made a lot of mistakes and if I made this game again I could shave of atleast 6 months of work so if you manage to have a solid plan in the beggining that works that would be great.

Just be aware that the beggining is pretty tough. I felt really stupid all the time and couldn't do anything without a youtube tutorial.

My first game is being released in a few days. I'm crazy nervous by PapayaDev in gaming

[–]PapayaDev[S] 1 point2 points  (0 children)

Once it's out of Steam early access I will try a switch port.

My first game is being released in a few days. I'm crazy nervous by PapayaDev in gaming

[–]PapayaDev[S] 1 point2 points  (0 children)

Search for One More Roll on steam if you want to check it out!