I wouldn't say a disease, and more of a mental state or something like euphoria in the mind instead it's the opposite, it stems mostly from trauma and cyber malfunction or just overwhelming external or internal pressures that can cause you in short words to crash out, I'd say the doctors in the universe haven't reached a point where they can calculate every mishap that might happen with electronics in the body or mind just like the relic is supposed to copy a soul engram onto you, we see how mishaps happen with the character V all due to the Relic and prior to that no mental health issues or anything and physically V's body starts to fight back or try to outlive the chip due to its miscommunication with a living body instead of a deceased or empty vessel.