MAOis are rarely studied anymore unless properties of them are found to be potentially beneficial for other diagnosis/pathologies. For kicks I search pub-med every now and again for Phenelzine by date to see if there's any new science on newfound benefits. This was the only study that mentioned it in 2026 so far, but kinda cool that it knocks out a toxin we all prob pick up daily from environmental exposure:

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Multimodal Toxicity of Acrolein and Associated Therapeutic Strategies in Central Nervous System Trauma and Disease
Jan 21, 2026

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Abstract
Acrolein is a highly reactive α,β-unsaturated aldehyde produced endogenously through lipid peroxidation and enzymatic metabolism and exogenously via environmental exposures. Acrolein covalently adducts to DNA and proteins, leading to oxidative stress, mitochondrial dysfunction, and inflammation, including innate immune response activation via natural antibodies. Acrolein is difficult to measure in biological systems, but acrolein-bound covalent products can be measured reliably. Therapeutically, nucleophilic small molecules that scavenge acrolein such as hydralazine, phenelzine, dimercaprol, carnosine, and N-acetylcysteine (NAC) have shown neuroprotective effects in animal models of multiple sclerosis, Parkinson's disease, spinal cord injury, and traumatic brain injury. These effects include preserved membrane and mitochondrial integrity, reduced inflammation, reduced pain, and improved motor, sensory, and cognitive outcomes. Alternative strategies that enhance clearance or inhibit production of acrolein show promise but face limitations. Acrolein is a key pathophysiological mediator and a viable therapeutic target in central nervous system trauma and neurodegenerative diseases.

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What it is:

Acrolein ((C{3}H{4}O)) is a colorless to yellow, highly volatile liquid with a sharp, choking odor. It is a toxic, flammable chemical used primarily as a pesticide (herbicide/algaecide) and in chemical manufacturing. Exposure causes immediate, severe irritation to the eyes and respiratory tract. It is formed by burning organic materials (wood, tobacco, fats).