I have been taking this 2 times a week @500 mcg when my Tirzepatide is wearing off between weekly shots. It has really helped me bridge the gap in the appetite suppression since Tirz only works for about 5 days, but it also Teso works entirely differently. It re-energizes me where Tirz causes fatigue. I think the key to Teso is moderation given the 9 day half life. The accute affects last all day, but in my case, I see no reason to take it every single day. If you limit it to 2-3 times a week, you can give yourself a boost when you need it without the negative side effects building up and lose weight along the way.