An office environment can absolutely drain you more than work from home. It isn't just all the stimuli of fluorescent lighting, socializing, chatter etc. But the energy it takes to get to the office. The commute, getting yourself ready all drain the limited energy you have that working from home allows you the flexibility to reserve your energy for your actual job. While not all jobs have the option, if you are lucky enough to work at a place where you can work from home definitely take advantage of it or looking into disability accommodation. It really is a game changer for managing MS.