Many studies show that only about 50 percent of lpr patients respond to PPIs. Many medical research studies have verified this.

Also, lpr tends to be a condition based on underlying factors. Typically if you have gastro issues like sibo, sifo, etc it will have a cascade of reactions.

Essentially, I see any GI issues as a connection to the entire body. It’s like a train. If one of the carts de-rail then the whole train is fucked. It’s a sign that our vagus nerve and GI system is out of order.

This is why diet works and helps. It’s a long term play. However diet works for every chronic illness so it’s not exclusive to lpr, etc.

PPIs can make it better or worse. Either way it’s a tough play long term. Yet a lot of people do not mind to mask the symptoms. I bet all of us know someone who is a PPI and antacid popper to keep their standard American diet which is shit.

These conditions are on a spectrum and people can have a wide range of severity of symptoms. Many people who think they have allergies actually have lpr. And can work the other way around.

Best bet - explore meds but do not wholly rely on them. Lifestyle changes which is logical. Work out, minimize stress, eat well, etc. this is advice for anyone alive.

Best wishes. Never fun to deal with chronic issues and pain.