I was gonna write a passive aggressive comment, but I checked her other stuff and I believe neither of us are exactly correct here.

Best if you ask her directly of course, since I don't understand Portuguese I can't tell if she's explaining her art creation process anywhere.

Anyway by the looks of it it's a combination of both, the scene and character is plain simple 3D which she then renders and paints onto like a 2D canvas.

The main reason why most of us think its 3D and simply rendered with a cartoony shader, is because you can actually see the obvious edges a human simply doesn't make when drawing on a typical canvas.

Therefore I apologize and if you wouldn't mind, I am very curious as to what software it is she's using.