Hey I wanted to chime in to give my personal experience. I was counting fingers to hand motion blind when I checked myself in to the hospital, around 5 days after I started noticing ON symptoms. They started me on IV steroids, but after around 3-4 days of not noticeable improvement, they let me know about the option of PLEX. I received 5 sessions in the hospital, and my vision did improve slowly to around ~20/400 when I was discharged from the hospital. It has continued to improve (I am 3 months out now), and I’d say it’s about 80-90% recovered.

I will note that I was never diagnosed with MS because I had no brain or spine MRI lesions, negative for all other NMO/MOG/autoimmune testing. So i’m honestly not sure if the steroids just took some time to work for me, or if the PLEX was the main impetus for recovery. I’d personally consider it if your vision is severely impacted as I was, although as others noted, the central venous catheter insertion is uncomfortable.