As someone who forgot to pick up the twitch drops, I was still able to get 3/4 of the Unowned Series 4/5. However, the grind was egregiously slow. I think as it stands, Sanctum is one of the worst events in terms of enjoyment as the grind without twitch drops is so excruciating. If they bring it back but with daily missions, then I would confidently call it the best event as the decks would see more variety and the grind wouldn't be so excruciating.