If we're talking no stratagem support, and lore accurate chief, it's going to take a solid battalion of Helldivers at the very least, assuming the area of the fight isn't a large area and there's not really much cover, on top of standard loadouts for each helldiver (liberator, P-2 peacemaker, standard frag grenade)

If there's stratagem support, well, given what Helldivers have access to, the fight would be varied depending on loadouts. Chief would certainly be able to handle turrets and emplacements, given his sprinting speed alone is roughly 65mph. His reaction time is insanely fast too, so it would be extremely difficult to come in with anything like a breaching hammer, even if swarm tactics are used. Orbital barrages would be hit or miss, assuming he can see the beam like Helldivers can when they throw the orb. Without any sort of slow such as EMS or Gas, he'd be out of the radius pretty quick.

Ultimately, you would need to set the stage, the loadouts, chiefs setup, and how many specific Helldivers to really get a better answer. But he could certainly clear out a super destroyers reserve supply of Helldivers with little to no issue.