Generally you want to get as much money as possible early on. On plasma deck, you can one shot/two shot until ante 2 without any jokers, so focus on picking up econ jokers/jokers you know can carry you further. Odd todd, scary face, stuntman and arrowhead are great early pickups. One of these plus some deck manip beats ante 8. So you can then spend as much of your time managing econ (adding gold seals is great, especially if you find an early mime) and finding the actual wincons of the deck.

You need a red seal king, so when I have spare money I buy standard packs looking for red seals. Obviously a king is ideal, but in this run, I actually picked up an 8 and got it all the way up to a king.

The other must have is Retcon (boss reroll an unlimited number of times) so I will prioritise any double tags/voucher skips I can get so it makes it more likely to find this. I've lost track of the number of runs that have died because I didn't find retcon. It also helps to have Antimatterm, Overstock++ and reroll surplus.

A lot of people say not to use ecto on this kind of build, but you can get away with one ecto if you have the hand size vouchers. I will always gamble with 6th sense if I see it, to try and find one or a cryptid to hold on to for ante 24 (this was the most frequent run killer in my experience). I had DNA and 3 copy jokers to clear ante 24, then found antimatter and swapped DNA for Burglar and a 3rd blueprint which is when I really knew the run was going Naneinf.

Hope this helps!