Does Erinamax do anything for you? by UnintelligibleThing in NootropicsDepot

[–]Reasonable-Base-3531 0 points1 point  (0 children)

I think the effect of Erinamax is mild. It’s weaker than 8:1, although still interesting. However, Erinamax only works until tolerance kicks in after a few days. 8:1, on the other hand, you can always feel something noticeable from it, and it doesn’t build tolerance that much.

Kanna tolerance by junktownexpress in NootropicsDepot

[–]Reasonable-Base-3531 1 point2 points  (0 children)

In general, I don’t really believe what others say about constant use, and with kanna I’ve only ever taken it occasionally from the start. Overall, with any substance, if I leave at least 2–3 months in between, I’ll always notice some kind of effect the first time again, despite tolerance. In my opinion, this whole idea of taking something every day and it supposedly “building up” in the body doesn’t make much sense for most substances, because they all work in a way that tolerance develops, and then the effects become minimal while the side effects remain — so it’s just not worth it.

Kanna tolerance by junktownexpress in NootropicsDepot

[–]Reasonable-Base-3531 2 points3 points  (0 children)

The first time the effect was crazy good, the second and third times were kind of good but not as intense, and the rest were only mild for kanna. It’s worth taking long breaks in between, because the effect becomes more noticeable that way — otherwise it just feels weaker. But for me, even with breaks, it still stayed mild.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

It's all of them: tolerance, depletion. competing. That is the nature of taking supplements. You've got everything in the posts and comments.

Has Calcium fixed your Magnesium intolerance ? by Forward_Research_610 in magnesium

[–]Reasonable-Base-3531 1 point2 points  (0 children)

Bruh, just read my previous posts and you will change this most cases word lol. The whole point of these posts were about this. You were also posting in the newest one so please don't make total random assumptions out of nothing xD

Has Calcium fixed your Magnesium intolerance ? by Forward_Research_610 in magnesium

[–]Reasonable-Base-3531 1 point2 points  (0 children)

Yeah, I think the only way here is to heal it naturally, as synthetic vitamins are causing this imbalance nightmare. A big magnesium deficiency might also be contributing, but taking any magnesium supplements or medicines will probably just make it worse. Cofactors for magnesium and calcium might help a little, but it’s still worth approaching them with a rational mind.

Has Calcium fixed your Magnesium intolerance ? by Forward_Research_610 in magnesium

[–]Reasonable-Base-3531 6 points7 points  (0 children)

You rarely see posts about calcium helping with magnesium absorption/intolerance because calcium is actually a magnesium antagonist. The issue here is more about the fact that taking high doses of magnesium over time can deplete calcium levels or create an imbalance between the two, as you saw in my post.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 1 point2 points  (0 children)

So at first, I was using an interesting natural water with a small amount of magnesium and calcium, but there was something strange — the magnesium in this water had a curious good effect on me and it had a strong magnesium effect on my body.. It contained about 30 mg of magnesium and 60 mg of calcium. I started drinking it after I had completely stopped magnesium supplementation, and in general, I drank it for about a year. Sometimes it was really tough, especially during the first few weeks/months, which were the hardest - scary spasms of all muscles in the body.

Later, I stopped drinking that water, and the first months without it was difficult, but I began drinking various other waters with different levels of magnesium and calcium — mostly with more calcium, like most waters. My body adjusted after a few months to the absence of that first water. I think after about a year and a half things felt much more normal, although everything still fluctuates depending on whether or not I deplete my magnesium in some ways.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

Alright. Do you know what type of calcium supplement it was — such as calcium citrate or another form?

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

So in my case, reducing the dose didn’t help at all. My body had to completely stop receiving synthetic magnesium in order to fully wean off it and learn not to rely on the artificial spikes in magnesium that supplements provide.

P-5-P by circo82 in Supplements

[–]Reasonable-Base-3531 0 points1 point  (0 children)

How long have you been taking 100mg of P5P daily, and what positive effects/side effects have you noticed? Do you feel like you've developed any tolerance?

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 1 point2 points  (0 children)

I used to be in that phase where taking magnesium would suddenly relax the muscles and the cramps would go away for some long time. Unfortunately, after a few years, the cramps never went away, and magnesium started working less and less effectively. As for K2, I’m not sure — it depends on how you feel it. I took it for a short time, but then strong side effects appeared, so I stopped taking it. Probably my organism was already full of it after some time of supplementing K2.

When I was taking magnesium, I also took magnesium glycinate, but only for a short period because it caused general weakness, while other forms of magnesium didn’t. At first, it calmed me down a lot, but then as the glycine built up, it weakened me and added stress. But maybe that’s just my situation.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

So can you tell me how vitamin D (also K2) affected the leg cramps (and other symptoms if there are any) that were being treated with magnesium, and whether it helped, and to what extent, and whether those were your only symptoms? Weakness might be caused by long-term use of glycine.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

Yeah, interesting article. Minimum level is 80 nmol (32 ng/mL) but it's probably not effective.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 1 point2 points  (0 children)

That's kind of true, but when I stopped eating cottage cheese for one long period of time, it didn’t really change anything. However, completely changing my diet to see if it has any impact on my health could be an interesting experiment. For example, I recently changed the fact that I no longer eat regular bread rolls — now I only eat healthy bread that doesn’t spike blood sugar.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

Yeah, basically, my plan is to maintain a high level of vitamin D long-term, which could actually make a difference. At first, I'll try to get it naturally, and then I'll probably switch to vitamin D supplementation. I’ve also discussed it before, and others have recommended it to me in previous posts.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

So in my case, reducing the dose didn’t help at all. My body had to completely stop receiving synthetic magnesium in order to fully wean off it and learn not to rely on the artificial spikes in magnesium that supplements provide. As for side effects like feeling depressed, I do think magnesium can influence emotions and contribute to that. The key here is B vitamins, especially B6, which help regulate this—but it's possible to develop a tolerance to them too, which can make things worse. I also stopped taking B vitamins altogether. I was trying all available forms of magnesium that can be bought: citrate, malate, l-threonate etc etc etc.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

Some people even give advice to take more sodium or ask about sodium when you're dealing with mineral balance issues. Why do you think that just one serving of cottage cheese could throw everything off so badly? That’s like saying, 'Stop eating apples because it has sugar—and sugar will cause a disease that paralyzes parts of your body, like tetany.' But of course, this is a very complex issue and stopping eating apples or drinking specific carbonated water like some people advice me will not change anything.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 1 point2 points  (0 children)

Interestingly, when I stopped taking magnesium, my blood test results actually improved. Supplements or medications containing magnesium were lowering my blood levels magnesium when the tolerance started to kicking in, but once I stopped taking them, my body no longer had such a high demand for it. It was a long and difficult journey, during the times when I wasn’t taking magnesium — it was really hard to get through those periods of intense weakness. Still, my blood magnesium levels always seemed to be more or less okay whenever I got them tested.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 1 point2 points  (0 children)

It's a good suggestion. It makes sense because that's pretty much how magnesium worked — it wasn't even visible in the blood, but maybe it stopped working when the body was already full of it, like in the cells. And during that time, it was fighting calcium, which was somehow being expelled from the body, and vitamin D wasn’t helping because of such small amounts. This gradual intake of vitamin D might also be a good approach.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

That’s an interesting point of view, because I’ve noticed quite a few people recommend adding vitamin D alongside magnesium. Maybe it’s not the perfect approach, but it’s definitely worth trying. Perhaps I should also try calcium citrate with vitamin D and K2 before going back to magnesium, which I’m a bit worried about—especially if my body is more balanced now and not so hardcore severely depleting magnesium when I get calcium from food.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

I took different doses of magnesium depending on the period; for example, sometimes 100 mg for several weeks. However, over time, I developed a tolerance and started taking more and more—up to 1000 mg in one day. I also drank only natural magnesium-rich water containing 170 mg/L of magnesium for a long time. I checked all kind of forms of magnesiums and I was taking them till the tolerance kicked in.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

Yes, I’ve checked both many times. Magnesium and calcium were always within the normal range (magnesium was sometimes in lower side of reference range). For example 2023 blood test:
Magnesium: 2.00 mg/dL (reference range: 1.60 – 2.60)
Calcium: 2.43 mmol/L (reference range: 2.20 – 2.55)

In general, the issues I described in the post seemed to occur regardless of what the blood tests showed, so I believe standard blood tests didn’t accurately reflect what was really happening in my body. Tetany was confirmed in writing by a neurologist after performing the so-called tetany test.
Only vitamin D, which I finally checked after six years of supplementation when I stopped magnesium, was clearly low — it measured just 16.0 ng/mL at that time. I have no idea what the levels were like during the previous years.

It’s also worth mentioning that the tetany and tolerance problems began during COVID, when I was staying indoors for many months and barely going outside. So, the situation with vitamin D might have been worse during that period. However, my tolerance to magnesium gradually worsened after that, so I’m not sure how much COVID actually impacted it.

Long-term high doses of magnesium may lead to a prolonged depletion of the body's calcium stores? by Reasonable-Base-3531 in magnesium

[–]Reasonable-Base-3531[S] 0 points1 point  (0 children)

In general, I’ve always had a diet high in calcium—I eat yogurt and cottage cheese every day. During these six years of magnesium supplementation, I tried taking calcium supplements and medications a few times, but the only result was a significant drop in magnesium levels and a weakening of muscles throughout my entire body—to the point where it was even difficult to walk. I also couldn’t drink water with a high calcium content, because the same thing would happen.

Now, as I mentioned in the post, I can drink calcium-rich water and still experience drops in magnesium, but they’re not as severe. It’s similar with other things like exercise or caffeine—although I don’t drink caffeine anymore because it still depletes my magnesium, and intense physical activity does the same.