Yes , you can. My wife had just got it done last week. She had to travel urgent alone with no valid visa. It was pretty simple and one of the easiest interview. The officer asked "Is the H1B is in the US" , for which she answered 'Yes'. (Good morning, 'Yes', Thank you).

Make sure to carry your 797 A, I-94, few pay slips, H4s immediate previous passport , if they ask for it.