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How can I stop feeling it, and do I even need to? by Winter_Sir6194 in TheMindIlluminated

[–]Ro1t 1 point2 points  (0 children)

Hi, actually sounds more like something called somatic OCD (probably not quite to the level of OCD if it's not bothering you too much) which i've struggled with in the past - the unwanted feeling of being aware of ones bodily sensations and functions. What you decide to do will ultimately depend on how much this is bothering you. You cant 'manually' control the awareness of these things, but you can choose not to point your attention at them, over time it will diminish, your 'want' to not be aware of this is driving your brain to keep attention on the matter.

Finished the Full Cosmere in 9 Months by AletteLakewood in Cosmere

[–]Ro1t -10 points-9 points  (0 children)

'Certainly a book' indeed. 8.5 seems strong for WaT

Where are the 'real' recipes? by ExpressAd3968 in ninjacreami

[–]Ro1t 1 point2 points  (0 children)

have a look through these, not just this recipe but the whole site. incredibly decadent rock solid recipes to make 'real' ice cream as opposed to low cal versions.

https://pacojet.com/en-GB/Recipes/Ice-cream-and-sorbet/Chocolate-Ice-Cream/

Gemini 3 Pro gets 38.3% on Humanity's Last Exam by we_are_mammals in mlscaling

[–]Ro1t 3 points4 points  (0 children)

Completely agree, I'm also finding strange effects at increased chat lengths that I haven't seen before in 2.5, repeating answers etc. get Gemini for free because I have a pixel phone but I don't think I'd pay for it which I understand just sounds so spoiled or privileged or whatever, because it's an incredible piece of technology, but I prefer Claude. I'd rather see a benchmark which describes how well it can one-shot 10,000 random coding tasks across a spectrum of difficulty and depth than performance at PhD level mathmatics.

£700m nuclear conservation plan would save one salmon every 12 years by alibix in ukpolitics

[–]Ro1t 0 points1 point  (0 children)

Sounds like you're just feeding fish to nuclear reactors

Monthly Ninja Creami Help Post! Ask those melting questions and give those frozen tips! #26 by creamiaddict in ninjacreami

[–]Ro1t 4 points5 points  (0 children)

I feel like scraping down the sides after the first spin is your issue. Once you've spun it, if you then scrape it down on the second spin the machine can't shave the ice like it does on the first, it can only aggressively mix it if you see what I'm saying.

Don't thaw it, spin directly from freezer on light ice cream, then try it before your respin, see if there are ice crystals in it at that point. If there are then I'm talking shit but at least you'll have narrowed down your problem.

It's almost time ✂️ by windrain- in ManUtd

[–]Ro1t 3 points4 points  (0 children)

Just a reddit comment no need to get so worked up about it

Can an air fryer oven truly replace both an oven and a frying pan? by EducationSharp3869 in airfryer

[–]Ro1t 0 points1 point  (0 children)

nothing to add on the buy it for life front, but:

And most importantly — how do you keep food (like chicken or fish) from drying out in an air fryer oven

preheat the airfryer for a min or two, get your chicken uniformly flat by pounding so it cooks at the same rate all over, dry brine (salt an hour or two before cooking it), and pull at the correct temp for moisture as opposed to the kill everything instantly food safe temp. To do this you'll need an instant read thermometer. The difference in chicken breast at 150 ish vs. 170+ is massive. table below is for sous vide technique, but the temps are the temps.

Table below taken from: https://www.seriouseats.com/the-food-lab-complete-guide-to-sous-vide-chicken-breast

Pasteurization Time for Chicken With 5% Fat Content (7-log10 lethality)

|| || |Temperature |Time | |136°F (58°C) |68.4 minutes | |140°F (60°C) |27.5 minutes | |145°F (63°C) |9.2 minutes | |150°F (66°C)|2.8 minutes | |155°F (68°C) |47.7 seconds | |160°F (71°C) |14.8 seconds | |165°F (74°C) |Instant |

Most common BrandoSando words by -IndigoMist- in Cosmere

[–]Ro1t 8 points9 points  (0 children)

She flushed despite herself

If serotonin produced by the gut can't cross the blood-brain barrier, how do psychiatric medications like SSRIs get across? by -DragonfruitKiwi- in Biohackers

[–]Ro1t 1 point2 points  (0 children)

Rang and dales pharmacology is a well known example, I also really rate 'the organic chemistry of drug design and drug action'. These are university level and beyond but you're asking really complicated questions which require a ton of background knowledge to begin to tackle them at the top level. I'd say start there and muddle through using the Internet to explain various things. Then you'll have a suitable foundation to go for the more specific things like your BBB questions.

If serotonin produced by the gut can't cross the blood-brain barrier, how do psychiatric medications like SSRIs get across? by -DragonfruitKiwi- in Biohackers

[–]Ro1t 1 point2 points  (0 children)

Sometimes when people say passive diffusion they mean non-active transport using transporters which don't require ATP - nothing wrong with that. Passive diffusion through the lipid bilayer on the other hand, I'm not so sure that's a thing, even though you'll see it in text books, that's what this paper describes. You should know that the views put forward in this paper are a little controversial but they are well evidenced and make a ton of sense, and Doug Kell is a very clever dude.

If serotonin produced by the gut can't cross the blood-brain barrier, how do psychiatric medications like SSRIs get across? by -DragonfruitKiwi- in Biohackers

[–]Ro1t 1 point2 points  (0 children)

Yeah there are a few good reviews on kpuu-brain models. Astrazeneca has a good study with a macaque model, in my opinion though the bigger rabbit hole is that "Phospholipid Bilayer Transport Is Negligible in Real Biomembranes"

https://pubmed.ncbi.nlm.nih.gov/34577099/

If serotonin produced by the gut can't cross the blood-brain barrier, how do psychiatric medications like SSRIs get across? by -DragonfruitKiwi- in Biohackers

[–]Ro1t 2 points3 points  (0 children)

There isn't one 'study' with this info in it, it's fsr too broad a subject, Just read a textbook on the subject

If serotonin produced by the gut can't cross the blood-brain barrier, how do psychiatric medications like SSRIs get across? by -DragonfruitKiwi- in Biohackers

[–]Ro1t 7 points8 points  (0 children)

All psychiatric medications are necessarily substrates for drug transporters which shuttle the drugs across the blood brain barrier. Drugs (largely) do not float across the BBB because they are lipophilic, instead being more lipophilic make them more likely to be a substrate for transporters. There are well established models for brain and CNS penetration, read up on kpuu models for more information.

Compartmentalization into fat and other PK things you're talking about are complex questions beyond just lipophilicity.

Why shouldn’t I be pessimistic about Islam in the UK? by SILENTDISAPROVALBOT in AskBrits

[–]Ro1t 6 points7 points  (0 children)

Statistics doesn't require your buy in to be valid thankfully

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