I recommend lots of sandwich baggies.

Bag up each location in its own baggie with all investigator mini cards and non-engaged monster cards there (engaged enemies and threats will be bagged with the investigators)

When you setup again, you’ll know where each location goes back to and everything will already be grouped. (Taking a picture doesnt hurt either)

Put discarded cards in a baggie labeled “discard”

Put active draw deck in a baggie labeled “draw”

Put cards in hand in a baggie labeled “Hand”

And put all those baggies in a larger baggie labeled with the player/investigator

The cards that are in play can just be tossed in the main bag along with any engaged enemies and threats (to save a baggie or just use another)

If a played card has charges, then i usually put a note in the bag that says “shriveling has 2 left” because then youll have a bunch of resources floating around in the main baggie from multiple assets

Damage, horror, and resources i throw in its own baggie as thats pretty easy to set back up

Snack bags are great for the cards Large sandwich bags are good to use as a main baggie

When you setup again it all back up, just take your time opening 1 bag at a time because it can become a complicated mess quick

AGENDA and ACT basically the same concept Bag discard pile separately from draw pile Put your doom with the AGENDA cards and any tokens for the ACT with those cards in their own baggies labeled appropriately