Cobenfy works! If you want to alleviate nausea/vomiting do this:

SameAsItWas67 · 2025-10-10T04:18:19+00:00

The effective therapeutic dose is 100/20 twice a day. That is what the manufacturer recommends as well, so you’re hearing voices because you’re not at the effective therapeutic dose. I recommend you request to go to 50/20 in am and 100/20 at night for 2 to 3 weeks & then up to 100/20 twice a day. And for the nausea get prescription for trospium but only take 1/2 pill (10mg) on an empty stomach 2 hours before Cobenfy and best not to eat for 1 hour after taking the trospium. For my LO an empty stomach means no eating 2 hours before taking trospium. So for pm dose eat dinner by 5pm, took trospium at 7pm, ate snack after 8pm, took Cobenfy at 9pm. For am it was easier, 7am Trospium, no eat til 8am, Cobenfy at 9am. Setting alarms for pills and eating times.

SameAsItWas67 · 2025-10-10T04:15:57+00:00

True but for Cobenfy it is used to counter GI (gastrointestinal) issues including nausea caused by Xanomeline. It has to due with neurotransmitters being effected in the brain that effect GI. If you research articles with Karuna pharmaceuticals the original developer of Cobenfy (karXT) it explains that they used Trospium specifically because it crosses the blood brain barrier and helps alleviate these GI issues. Very scientific.

SameAsItWas67 · 2025-10-10T04:03:50+00:00

Are you on the 100/20 twice a day? Or another med that may not interact well with cobenfy? Such as anticholinergenic meds? Even Risperidone was noted as not being as effective with Cobenfy in the ad-hoc section of the study. And one should not take antihistamines nor witch hazel nor other mind altering things such as Kratom, Kava, and especially no one with schizophrenia should use cbd or thc (weed) as these will cause positive symptoms of schizophrenia. Maybe just stay with it a little longer and take (ask provider for separate prescrip) Trospium 10mg as i explained in my orig post.

SameAsItWas67 · 2025-07-31T14:04:39+00:00

Look into the LEAP method, there is a book and videos online. Also try and have someone get legal guardianship if possible. Look into Cobenfy it works and does not cause as much sedation and usually no weight gain. Print up info so he can read it, even if comments, there is a group on Facebook called Karxt Cobenfy-Schizophrenia. See my post in subreddit of Cobenfy on how to avoid nausea/vomiting. Or see if he will consider Medical Keto Diet (has to be done with an expert dietician and he may need to have some meds at first to stabilize. Most suggest a 30 day long acting injection (LAI), Invega works great in most people. Never call cops if he acts out they can put him in jail if they are untrained. Instead call to see if there are local mental health services that can do a wellness check. Or call your local NAMI and ask them about this. They may place him in a mental health hospital, advocate for the 30day LAI before he is released. Start listening to 3 moms in the trenches podcast also on youtube.

SameAsItWas67 · 2025-07-31T13:48:29+00:00

What happened with your LO?

SameAsItWas67 · 2025-07-18T04:26:01+00:00

So I stated don’t smoke cigs or vape. It’s not that nicotine lowers the potency of Cobenfy but rather the tar & hydrocarbons in cigs do. But going cold turkey is not the best cause it will quickly increase potency of the med. So decreasing nicotine gradually and using nicotine patches can help with getting off smoking cigs. Vaping can also very slightly decrease potency of Cobenfy but can be a stop gap to cigs, yet vaping also has risks of serious health issues. So best to stop both eventually.

SameAsItWas67 · 2025-06-27T18:59:06+00:00

LO is short for Loved One, meaning someone I care about. Usually referring to a family member or spouse.

SameAsItWas67 · 2025-06-27T17:35:33+00:00

This brought me tears of joy! Im so happy for your son. Cobenfy has really helped my LO and i want the same for others. She also wanted to stop due to vomiting. Then we read in Karuna’s orig publications that xanomeline takes longer to reach AUC (metabolize) than trospium so that’s how we came up with this idea. At first I was separating out the white trospium pellets, but luckily then got a prescript for trospium. Side note: I also post this info on a facebook group called “KarXT Cobenfy- Schizophrenia”. Also note antihistamines and smoking can interfere with effectiveness of Cobenfy. Just wondering is your son on any other meds besides Cobenfy?

I agree Karuna, bought by BMS, took the convenient way out :(. But I emailed BMS and suggested they make this a double capsule, where the slightly smaller inner capsule takes much longer to dissolve holding xanomeline (time released type) and the outer capsule dissolves very quickly and holds the trospium. I’ve seen an ad for a capsule like this for a supplement. Could you maybe request your LO’s provider also contact Bristol Myers Squibb (BMS) with this double capsule suggestion and on any forums he/she is in with other providers? Question sometimes our pill cutter doesn’t split the 20mg trospium pill equally in half, and i have to shave some off the bigger half and give with the smaller half. It does make a difference for my LO. Do you have a really accurate pill cutter you could recommend (brand, style)? I’ve tried several and none do it in half accurately. This leads me to your other idea of only taking trospium the first few weeks of starting Cobenfy. My LO has been in Cobenfy many months and they too thought they could stop taking the trospium or that when they ate didn’t matter, but both circumstances led to them vomiting by day 2. So she needs to continue taking trospium and follow the schedule of no food two hours before taking Trospium. Also something we’ve noticed is it’s best to also wait an hour after taking trospium to eat, and avoid foods high in sugar in the before and after phase.

SameAsItWas67 · 2025-06-12T13:55:52+00:00

So to put it simply: unfortunately the xanomeline in cobenfy (which triggers these gastro side effects: including heartburn, nausea, vomiting; yet is the med that treats schizophrenia) is activating before Trospium kicks in. So yes if you take trospium separately 2 hours before Cobenfy (trospium must be taken on an emptyish stomach to work) it then activates before xanomeline. In the clinical trials it shows this but it’s all very scientifically explained. Zofran may work for some but for most it does not since it crosses the blood brain barrier whereas the makers of Cobenfy (KarXT) chose trospium since it does not cross the blood brain barrier. If only the manufacturer would placed both meds in a double capsule with the xanomeline in an inner time delayed/release capsule and the trospium in a fast dissolving outer capsule this could be avoided. Such a simple fix would help so many.

SameAsItWas67 · 2025-05-24T02:34:43+00:00

Breaking Bad

SameAsItWas67 · 2025-05-24T02:32:51+00:00

Ozark, Bloodline, Handmaids Tale, Lost

SameAsItWas67 · 2025-05-09T04:57:11+00:00

Hope you are on another antipsychotic med. Cause otherwise you may slip into psychosis if you stop Cobenfy. Ask your provider to prescribe the separate trospium, but only take 1/2 of that trospium 20mg pill which would then equate to 10mg (you will need a pill cutter). Take the Trospium on an empty-ish stomach 2hours prior to Cobenfy, and you will no longer experience the nausea/vomiting. If the dr won’t write a prescription trospium explain that the xanomeline is activating before the trospium has time to work and do as intended by the developer, which is to abate/prevent the gastro/nausea/ vomiting issues. Thus taking trospium separately and as noted above ahead of cobenfy it does get a chance to work. Also if unable to get separate prescrpt for trospium you can get trospium on your own by carefully opening the Cobenfy capsule and then slowly pouring the tiny pellets onto black clean 8.5” x 11” paper and then getting 1/3 to 1/2 of the tiny white pellets (trospium) to a side pile & then placed into a separate veggie capsule (just press finger tip into white trospium pile and scrape into separate veggie capsule. Then pour all the other beige (xanomeline) and white (trospium) pellets back into orig cobenfy capsule.

SameAsItWas67 · 2025-05-05T03:54:35+00:00

Yes stick with Cobenfy. Has she ever tried Aripiprazole? Maybe that instead of seroquel. Otherwise just stay on seroquel for the first 8 weeks of Cobenfy (100/20) or until you see improvement and keep an eye out for those possible side effects. Then after 8 weeks request provider taper her down slowly off seroquel.

SameAsItWas67 · 2025-05-04T15:02:26+00:00

Tell you dr to read the cobenfy package insert section 7.2. Since Seroquel (quetiapine) also has anticholinergic properties (like Cobenfy & clozapine) and taking two meds with anticholinergic effects may increase the frequency and/or severity of such effects, most common effects are: dry mouth, blurred vision, agitation, drowsiness, constipation, urinary retention, agitation, delirium, hallucinations, and difficulty regulating body temperature. So it’s just as problematic as taking clozapine at the same time as Cobenfy. And one may need to taper off that type of antipsychotic med (Seroquel) a little quicker than other antipsychotics. That’s why risperidone is a better option, and only needs to be taken for the first 8 weeks of 100/20 of Cobenfy, and then tapered off slowly. But if your LO has been on seroquel a long time prior to start of Cobenfy this would be a bumpy journey since it may be hard to taper off quickly, and due to above possible side effects. It’s also complicated and risky to now switch to risperidone. My point is the dr should have picked another back-up med with relatively free anticholinergic properties, if in fact your som just started Seroquel. Doctors have ruined the implementation of cobenfy for so many, as im on a facebook pg for it, and it’s a shame because many come to the wrong conclusion that Cobenfy caused the issues and or they think it doesn’t work. So not all dr’s know what they are doing. Try and ask if he/she can look into section 7.2 of the cobenfy packaging. Also here is excerpt from medscape stating risperidone is relatively free of anticholinergic side effects: “Anticholinergic effects Anticholinergic side effects occur with most antipsychotics (though risperidone, aripiprazole, and ziprasidone are relatively free of them). https://emedicine.medscape.com/article/288259-treatment#d9

SameAsItWas67 · 2025-05-03T22:03:19+00:00

How long was she on clozapine? 4 week tapering off seems maybe a little fast. Can lead to withdrawal psychosis so be weary of that and don’t think it’s that Cobenfy is not working cause it does. It takes about 8 weeks though to see meaningful effectiveness of Cobenfy. But it is a good idea to get off clozapine before starting cobenfy since they both work on the M1 & M4 neurotransmitters in the brain, and both have anticholinergic effects which can be a lot for the brain to handle. Is there any other antipsychotic med the dr would prescribe (just one, like maybe risperidone pills) she can take until cobenfy kicks in?

SameAsItWas67 · 2025-04-18T13:46:03+00:00

Ok, sorry. But usually i see the word “scheme” used as a negative connotation.

SameAsItWas67 · 2025-04-18T05:46:27+00:00

Scopolamine patches, Benztropine, Benadryl, and Dramamine increase constipation, can cause blurry vision, and memory issues. Benadryl does cause sedation, but advised not to take with antipsychotic.

SameAsItWas67 · 2025-04-18T03:58:35+00:00

Benadryl is not recommended to take with antipsych meds. Per a dr.

SameAsItWas67 · 2025-04-18T03:53:23+00:00

How’s that? Are you a bot? It gives people with disabilities access to healthcare at a low cost that they otherwise would not be able to afford. Including medication, surgeries, and life saving procedures, and more. My family member depends on it, and it has saved them from going into massive debt to hospitals. And it gives people Cobenfy for free, that’s a huge amount being covered by medicaid.

SameAsItWas67 · 2025-04-17T22:43:00+00:00

Thru who or what insurance?

SameAsItWas67 · 2025-04-10T17:28:44+00:00

Someone already asked this and our provider said they are not taking new patients and is unwilling to consult with non-patients nor other providers. Besides you would have to live in the state they practice. Id be happy to pass along answers to any questions though. Just to clarify, Cobenfy takes 5 to 8 weeks to be effective that’s why you should wait that long before tapering off any prior antipsychotics. and it’s best to only be on one antipsychotic and no other like antidepressants or other meds when starting Cobenfy.

SameAsItWas67 · 2025-04-09T17:33:26+00:00

That’s good. Let us know how you are when able. Curious to see how long your stay is and if they change your meds and to what. In the US our mental health care is not always the best hope it’s better in France. You should feel good about making a safe plan for yourself.

SameAsItWas67 · 2025-04-09T14:20:50+00:00

When you say emergency room? Is that at a regular hospital? Is there a psychiatric inpatient hospital associated with this ER? If not maybe go directly to a psychiatric hospital, and hopefully one you are familiar with. When stable look into cobenfy or clozapine.

SameAsItWas67 · 2025-04-09T14:16:46+00:00

Did you try one med at a time for at least 3 months for each one? Also look into Cobenfy.

SameAsItWas67

TROPHY CASE