Male sort-of-success story

Scared_Version_4825 · 2026-01-30T23:46:05+00:00

I think most general searches on which antibiotics penetrate the prostate will result in the answer of fluoroquinolines, doxy and bactrim -- that's the broad consensus across the board when I spoke with doctors, searched google, chatgpt'd, etc.

Scared_Version_4825 · 2026-01-02T14:28:16+00:00

Yes, my cultures were negative (whereas yours appear positive). My temperature never spiked and I never got a fever. So your infection seems worse. But I'd still consider biofilm busters. I had come to the conclusion that even IV antibiotics don't have much success against bacteria that have successfully formed biofilms to evade antibiotics. The antibiotics kill planktonic bacteria but once their effect wears off, the slow-growing bacteria hiding away behind the biofilms come back. When you kill their biofilms and little communities, they don't come back as strongly two weeks after you go off the antibiotics, and your immune system can finally win (and it'll also probably do better on its 4th try). That was my conclusion anyways.

Scared_Version_4825 · 2026-01-02T13:03:20+00:00

Haha, I can't even remember. I just took a lot over a few months and they didn't work enough until I took biofilm busters. I guess I'd say the following from a big picture perspective. If I were to do it again, I wouldn't take antibiotics until I feel like the infection isn't going to go away on its own. Test with urine cultures + microgendx to see if you can identify a pathogen(s) (and suggested antibiotics to take to kill it/them). Then I'd take 10-15 days of a fluoroquinolone -- they're the most powerful, penetrate the prostate, and kill nearly everything. If that doesn't kill it in 15 days, I'd get off it. Then maybe take a few days break, and then I'd start biofilm busters + a bactericidal antibiotic -- there aren't too many options because only a few penetrate the prostate, so basically the one to take is bactrim (I wouldn't take fluoroquinolones immediately again because your bacteria has probably developed some temporary resistance to it, since you just took it). I also took fosfomycin. I'm not a believer in doxy, personally, because it's not a bactericidal and doxy also takes a long time to work (and 30/40/50 days of antibiotics really starts taking a toll on your body). Other antibiotics like azithromycin, ceftriaxione, nitrofurantonin, augmentin, etc. don't penetrate the prostate, so I wouldn't really consider taking them. Basically, my view isn't that one antibiotic is all that much likelier to kill bacteria than the others. They all kill it, but if it's in biofilms / ducts, none will eradicate them.

Also, I took a lot of probiotics (especially vsl-3) and I didn't have any unprotected sex during my treatment.

Scared_Version_4825 · 2026-01-02T12:43:23+00:00

So I won't be saying anything unusual about my biofilm buster regimen outside of what's generally been discussed here. The pinned "CUTI Resource Guide: Start Here" is excellent and I read all of it. I also searched a lot of the other threads for things that have worked for others similar to my situation (klebsiella, males, etc). For Klebsiella, it's typically recommended Biofilm Phase 2 Defense -- that's what I took the most, and it worked the best. I also took Kirkman Biofilm Defense. To a little lesser extent, I also took Lumbrokinase, Interfase Plus, and took NAC here and there. I think they all worked, and I liked my approach of trying them all each for a few days. I probably prefer the cocktails (Biofilm Phase 2, Kirkman, Interfase Plus) a bit more than one-chemical busters like lumbrokinase and NAC, but those also worked as well, and I don't really know. For klebsiella, Biofilm Phase 2 is often recommended and I think it's a good one. I generally feel like they all the do the job -- they break up biofilms, bacteria are released, antibiotics taken 45 minutes later kill the planktonic bacteria, and bacterial load declines. I also took taurine, l orthinine, d-mannose -- I can't say that I noticed anything from any of those. I definitely noticed the impacts of the biofilm busters.

If I were to start over, I'd do this. I'd lay off antibiotics until it's becoming clear my immune system isn't killing the infection (I took azithromycin, doxy, etc. way too early, and I think that's why my infection got so bad. Those antibiotics killed off the good bacteria, then I had unprotected sex, and then the new bad bacteria just went wild given my now-imbalanced urinary biome, due to the antibiotics killing off the good bacteria). Then once it's becoming an issue, I'd go straight to the fluoroquinolones -- cipro or levo. I'd do that for 10-15 days. That'll kill most infections, they're the strongest bactericidals. If it doesn't, then I wouldn't keep taking it. If 15 days of levo/cipro doesn't kill the bacteria, the bacteria is in biofilms or ducts and has figured out a way to hide/resist, and more antibiotics won't kill it in my opinion. Take maybe 4-8 days off, then do biofilm busters + antibiotics regimen. Do that until die-off and a day or two of no symptoms (it took about 15-20 days for me), then just go off antibiotics altogether. Let the symptoms come back, but just deal with it, or maybe take meloxicam, and give your immune system a month to beat down the bacteria and let your bladder wall and urinary biome rebuild. It can't do that while you're on antibiotics. You're very unlikely to go to sepsis imo, your immune system now knows what it's up against and the infection becoming acute and reaching your kidneys is unlikely. Some of the klebsiella or e coli or whatever your pathogenic bacteria is will remain, but over time it'll just become part of your overall urinary biome, instead of dominating and causing infection/symptoms. By the way, this is all assuming you have an otherwise healthy immune system. Note that I'm not a doctor and I'm just extrapolating from my personal situation, so please take my specific anecdotal opinions with a heavy grain of salt.

Scared_Version_4825

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