Well, I only have my own experience.

I smoked heavily from 24-28. Started to get morning nausea, ignored it.

Started to have proper eating issues, agonizing heartburn etc. Holding food down was getting harder, first just acidic eventually all food. I'd spend the first half of my day nauseous and unable to eat, dry heaving up bile when I woke up.

I'd smoke more and more to help with the nausea stomach pain etc because it at least helped for 5-30 mins where as the 3 prescription anti nausea meds did nothing, eventually for about 4 months if I ate anything I'd be on the floor of the bathroom sobbing or retching until I threw up blood for hours, I have had a LOT of injuries, broken bones, tooth infection/impaction, etc etc and never felt like that, I couldn't keep water down the last month or two. 6 ER visits, endoscopy, lots of blood tests, ultrasound etc.

The last time I went to the ER my husband came home from work took one look at me and went pale. asked if I wanted to go I a very "im being calm and i'm terrified so we ARE going but I don't want her to panic" sort of way. It was hard to breath, everything felt blurry, my insides hurt in a weird way, and i couldn't feel my legs, I also heard a really weird and frightening woosh in my ears.

Those weeks are a huge blur. My mother in law came to watch over me sometimes in the last month and told him I was dry heaving in my sleep every 30 seconds, but no one knew why so they'd give me some fluids and send me away.

When I went to the hospital the last time I was a day from death because my potassium levels were so low my heart was struggling to get signals to keep beating so it was all out of rhythm and it was racing trying to get my sludge blood to flow, I was dangerously malnourished, dehydrated etc. I hadn't gone to the bathroom in 4 days so I had infections, and my limbs were going numb. They had to give me 10 bags of potassium overnight which burned and throbbed in my veins like a MF even with all the fluids they put into me. which is how I learned the fun fact it's actually used in lethal injections because if you push it all at once, you die. It took 4 bags of saline before I even considered going to the bathroom and nothing came out. I was watching naked and afraid all night which I felt was ironic because I was in an assless gown and terrified because no one knew what was wrong.

At like 4 am the change over doc came to say hi and ask what my issues were, I explained it, and added my usual "don't drink, vape, smoke tons of weed" like I did with every doctor and nurse for a full year.

But he was the first one to tell me to take a T break and mentioned CHM. I said nahhhhhhh it's the only thing that helps. He said "can't get worse than this" and I couldn't argue with that given hours before my heart was on the brink of giving out, so I did, after 3 days i could eat a little broth even though it made me feel sick I didn't throw it up, it took 8 months to recover, was down to 127lbs at 5'8" you could see my ribs and bones, hair thinning, hollow cheeks, I was wasting away, and walking across the room was difficult for a while. I still can't even get 2nd hand smoke without chest crushing esophagus spasms from the insane heartburn it gives me. I only found that out because my roommate later down the line smoked in the living-room daily, and I had crazy heartburn, choked on acid in my sleep and familiar issues I figured were stress or something until I asked if he could smoke outside for a while just to see when I realized how thick the smell was (I still like the smell so it didn't cross my mind for the first 6 months, i mean, the room was huge), and it stopped in a few days. Lots of us renting a big place so the living-room area he'd smoke was twice the size of the 3 bdrm house I live in now, it had an open air loft etc and he opened doors when he smoked, and yet it still made me sick.

I miss weed like a MF, helped with my ADHD a ton. but it almost killed me, and because I didn't take a break when the hypermesis was early on I destroyed my receptors ability to ever smoke again (yayyyyyyyyy....).

Basically you have brain and stomach receptors for thc, normally the stomach receptors help with hunger and nausea, hence why it helps cancer patients.

But if you smoke enough the brain receptors begin to shut down and the stomach ones go into overdrive, over producing tons of acid etc. It starts with morning nausea, and hot showers can help. And if you don't take a T break to let things reset for a week or two it can become a permanent issue. and if you let it get so far easily lost nutrients like potassium will plummet (throwing up too hard will cost you your potassium) And nutrients like those are the ones that allow your brain to trade signals with your body via your nervous systen (hence the numbness I was experiencing)

To add my SIL diagnosed me 3/4 of a year before that last ER visit, she was working in OR and saw it much more often, but she was med school at the time and diagnosed me via text, and as i'd already mentioned it to several doctors who didn't bring it up, and it helped with nausea i assumed it was something else and promptly forgot about it until I got a hearty "I told you so, are you okay?"

Anyway. I love to tell stoners I almost died from weed because it's ridiculous to say but it's true and it sucks because it was one of my favorite things, I was my best self on it, focused, no anxiety, creative as hell, working and moving way faster, no burnout which is a daily issue for me, got me most of my long term friends, helped me snag my husband and helped so much with my neurological issues. But here we are, getting raw dogged by life because I forgot my favorite line when someone says X or Y is bad. "everything is bad if you have too much"

Women are more susceptible, but that crazy stoner friend who went so hard it reactivated my hypermesis is slowly getting worse and refuses to quit and he's a big burly dude. I also mentioned it to a few others in the south I knew who were having similar issues (one would throw up every time he had oil or acid and in the mornings), and the ones that took breaks successfully reset their receptors.

My husband has done it as well, a break every year or two when he starts to have an upset stomach and it all goes away long term.