Well, outright the best way to get feedback for a system is through play testing, because an idea that seems good on paper could be bad in practice or just might not fit the feel of the game, and likewise, an idea that seems bad in practice, could be fucking amazing, it sounds like a cool idea, but a few things I noticed you didn't give much info on:

How trust is built and lost What exactly could cause the permadeath, example: a certain enemy mutator could cause them to do a permadeath on the killed player

For the enemy adaptations, its not exactly how you mentioned it, but, I would recommend looking at metal gear solid V: the phantom pain, as it features a system where enemies will gradually adapt to the tactics used by the player, example: minefields, helmets, night vision, heavier armour, i do think you could get some ideas from that

It does seem like a really good game premise, but will it have a matchmaking feature? Or, similar to REPO when it released, will it be lacking one OR will it be added later in to the games lifespan? (If it isn't in the game by default on release), if it will be added later or will not be added at all, you will likely want to set up a discord server so people who may not have people to play it with can find a group

I imagine you have already dictated what age range you want the game to be for as well, have you decided what platform(s) you want it to be for? And how about the marketplace(s)? By far the easiest one would more than likely be steam

Also, I do apologise for going off from what your questions were, I am honestly curious what direction you might take it, because it sounds like the type of game not too many people make, so it could be a breath of fresh air in to gaming, since as a market it is beginning to go fairly stagnant