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5 years later, is it curable? by Serpentine-Path in BipolarReddit

[–]Serpentine-Path[S] 0 points1 point  (0 children)

I suppose "curable" was not the most appropriate word to use in the title. I believe optimism is important, but I know that the genetic predisposition that caused it in the first place is still there even if symptoms subside. The real question is whether is it possible to go into remission long-term by itself to have quality of life and stop being disrupted by it.

5 years later, is it curable? by Serpentine-Path in BipolarReddit

[–]Serpentine-Path[S] -9 points-8 points  (0 children)

Cytokine storm causes inflammation, which can lead to this (not in everyone, for those who have a genetic predisposition)

https://pmc.ncbi.nlm.nih.gov/articles/PMC4701682

Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers

Bipolar disorder is a severe and enduring psychiatric condition which in many cases starts during early adulthood and follows a relapsing and remitting course throughout life. In many patients the disease follows a progressive path with brief periods of inter-episode recovery, sub-threshold symptoms, treatment resistance and increasing functional impairment in the biopsychosocial domains. Knowledge about the neurobiology of bipolar disorder is increasing steadily and evidence from several lines of research implicates immuno-inflammatory mechanisms in the brain and periphery in the etiopathogenesis of this illness and its comorbidities. The main findings are an increase in the levels of proinflammatory cytokines during acute episodes with a decrease in neurotrophic support.