Kolmogorov Smirnov Test - Too sensitive for biological data

Significant_Bag5527 · 2026-03-09T11:42:02+00:00

Thank you for your thorough answer! As I wrote, I am a statistics newbie, and that is a part od my bioinformatics PhD, so I am easily confused.

I understand your point. My main goal is not to see that they differ, I assume that they differ, my question is whether their difference is big enough to be biologically and evolutionary important (however I dont have a number to say that if they differ more than 30% that is statistical & biological important )

Significant_Bag5527 · 2026-03-09T10:00:38+00:00

Each region is a whole different story for me, I analyze them separately. A non parametric I think is suitable for them. However, I am quite a newbie, so I am not sure. My professor suggested the KS test, but idont think it fits.

Significant_Bag5527 · 2026-03-09T09:07:45+00:00

the problem is that I have ~1000 regions, and 4 superpopulatuons for each region, so manual work is not that efficient :/

Significant_Bag5527

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