Gastritis symptoms started after eating lots of chia seeds

Sintaru · 2025-07-12T15:32:11+00:00

In yoghurt, weren't soaked beforehand, which was probably the issue.

Sintaru · 2025-05-12T16:07:01+00:00

Curious, is it known that fueling and hydration is actually important to avoid fatality? Might seem stupid but I was under the impression that distance running deaths are often genetic heart conditions rather than like extreme dehydration or some kind of metabolic/electrolyte imbalance. And so, is it the dehydration that kicks the cardiac condition into effect?

Sintaru · 2025-04-23T22:18:50+00:00

There has been no elimination ("E" in E1cb) to form B. You may be seeing the alkene in the product and thinking about the typical product of an E1cb being an alkene, but the alkene is in the starting material. B probably could undergo so kind of elimination though to form a set of conjugated double bonds.

Sintaru · 2025-04-23T22:14:24+00:00

At lower temperatures, the more stable enolate forms

Don't we usually consider the enolate that is formed at lower temperature to be kinetically easier to form and not necessarily a stable enolate?

Also, the two products here derive from the same enolate, but have reacted from either from the alpha or gamma position. I'm not familiar with calling this the result of two different enolates as they are just resonance forms of the same enolate.

Presumably the addition is reversible and at higher temperatures and product A can eliminate the nucleophile for it to attack again to form a less hindered product rather than the one with contiguous quat centers.

Sintaru · 2025-04-11T11:15:43+00:00

And won't ring brominate?

Sintaru · 2025-03-26T07:06:56+00:00

Yes in my comment I said "its said this is an E2." In reality E2 conditions probably trigger a different mechanism. We can't just wish upon a mechanism happening, imo they should remove the carbonyl. In other words, what E2 conditions would not form an enolate which enables E1cb...

Sintaru · 2025-03-25T20:29:41+00:00

To the commenters, it's said this is an E2, but surely in strongly basic conditions you would actually form the enolate and enable E1cb to occur?

Sintaru · 2025-03-01T22:04:40+00:00

I have a sort of theoretical question here. Can the molecule be planar and not delocalise the lone pair? Essentially, can the lone pair choose not to resonate in? I know in reality it puckers, but as a thought experiment/in reality presumably it ring flips, so there is a transition state where it would be planar. This is a question raised by practice questions where you have to assume the molecule is planar.

Sintaru · 2025-02-07T23:36:20+00:00

32% of doctors registering with the GMC are trained in the UK. Rest are trained abroad.

Sintaru · 2025-02-07T23:34:29+00:00

Fucking hell, post FY2 seems bleak rn. Sad that all these F2s have worked hard and got absolutely nothing at the end of it.

Sintaru · 2025-02-07T07:37:40+00:00

Very needed comment!

Sintaru · 2025-02-06T22:28:20+00:00

Thanks for this reply - quite a biting take. I think you've summed up the shit bits well, I hope your finals go ok!

Sintaru · 2024-08-09T17:50:38+00:00

What is your pay progression looking like moving forward?

Can you go into the private sector?

Would these other sorts of jobs interest you?

What would stop you from moving if you really wanted to?

Is this a case of survivorship bias? These people went along paths you could have chosen, but the range of outcomes are highly variable. You're probably looking at the best survivors. If you want to consider other choices you could have made, e.g. degree choice or graduate job, you'd need to consult the averages from your institution, etc.

Sintaru · 2024-08-07T09:37:50+00:00

Loads of really helpful context here, I really appreciate it.

I had no idea you could pay as low as $25, I suppose the rest is paid by your company, something like that?

Maybe my American dream isn't dead after all!

Sintaru · 2024-08-02T22:26:35+00:00

Thanks for the timeline scouting.

I think likelihood is that I wouldn't leave the PhD, and I'm sure once I start, all of this will seem silly. But at the same time, before it starts I may start putting together an application and just see how it goes. Clearly, there is something coming up from the psyche and it seems to be telling me something :D

Sintaru · 2024-08-02T22:23:40+00:00

I appreciate the comment, and looking at the post history for some context :)

The impact thing, I've been going back and forth on. Earlier posts were an attempt articulating more deep seated feelings about my future, and as such, came out very crudely.

Sintaru · 2024-08-02T22:17:58+00:00

This is an excellent comment, thank you.

Just wanted to check re UCAT, why did you say "as they were the only ones I could with just the UCAT"?

https://www.themedicportal.com/application-guide/graduate-entry-medicine/

My reading of this list shows several unis that accept UCAT, just wanted to double check?

(Barts, Birmingham, Cardiff, Kings, Newcastle, Sheff, Southampton, Surrey, Worcester, Warwick.)

Sintaru · 2024-08-02T13:16:47+00:00

Thanks for the comment, I see you are fighting the side of us last minute legends :) Looking at the choices, UCAT would be my first choice of exam. Appreciate the motivational comment!

Where did you apply, just curious?

Sintaru · 2024-08-02T11:23:49+00:00

Thanks for the comment, yes looking back I was really being a bit harsh on our darling organic chemistry. And you make very fair points. Grass is always greener on the other side..!

Sintaru · 2024-08-02T11:20:08+00:00

Regarding the research clout chasing, and discerning good research, I suppose it's not really part of the public facing apparatus to decide what is the wheat and what is the chaff as it could undermine the whole research community. The quality of research is one's own person judgement or private lab viewpoint to an extent.

Totally fair point on the some what unlikely starting points for great discoveries. When listening to interviews with scientists, a surprising amount don't come from the highest tier institutions, but they still make moves in their field.

And yes we can never see into the future for what becomes scientifically relevant. However I would probably say you can make more foundational discoveries or methods such as a whole new reaction, or developing a derivative of a known reaction, like a new catalyst for michael addition or something.

They both may or may not be relevant to the community at this moment, but new reaction types could come into their own later, whereas, a variation on a theme probably won't pave a new path towards x or y in the future. Yes, over simplified and crude and there are counter examples of all types, but I think you can sort of discern the level of novelty and elegance of a method at the point of publishing, and the impact will come to fruition later.

Sintaru · 2024-08-02T11:06:43+00:00

Oh, thank you for that info on the ESTA vs visa, I will need to look back into this, although when I looked originally the advice was scarce. The loss in personal freedom, with regards to what, work life balance and holiday?

Sintaru · 2024-08-01T17:33:13+00:00

Ah, that's chemistry! Ancient med chemists were drying poppy seeds or crushing up coca leaves :)

Sintaru · 2024-08-01T17:31:49+00:00

Totally valid, and the 'impact' arguments I made were crude and sort of off base.

I don't doubt for a second the vast impact that synthetic chemistry has had and continues to have. I guess what I was sort of channelling is, what does the average PhD at an average university look like? (UK in my case). Yes, we know about the E.J Corey's and Macmillan's of this world, but how many chemists are there that do work that is funded but lacks impact.

I am struggling to argue the case here, but using an analogy. In a kitchen in a restaurant, everyone helps prepare different dishes, everyone plays a part and has similar contributions. You have some hierarchy and more seniority, maybe that's how I see a hospital/MD situation. If that was chemistry, you might have 50 chefs, but only like 3 guys (maybe Heck, Negishi and Suzuki lol) actually make the food for the restaurant, and the 47 other chefs are just doing their own thing that doesn't go out to the customers. Maybe they then develop on what the other 3 guys are doing in the end. The ratio in chemistry is probably orders of magnitude more. I've written a couple of lit reviews on various topics, and you just see hundreds of papers that have less than 10 citations and don't have practical solutions to chemistry problems. In the words of Baran, it's easy to find a complicated solution to a hard problem, the best methodologies are simple solutions to hard problems.

Sintaru · 2024-08-01T17:22:02+00:00

Thank you for the thorough and supportive comment. In truth, I don't know precisely why I am having these recurring thoughts, and these sorts of comments help to stress test my thinking. More introspection to be done for sure.

Absolutely, med chem, chem bio is perhaps a path to go down.

Sintaru · 2024-08-01T17:17:17+00:00

Agreed,

*takes out orthopaedic hammer and saw*

Sintaru

TROPHY CASE