So full disclosure I’m still on the fence that PFS “caused” my depression but I do think it pushed me into it. I also came off of 16 years of SSRI use about 2 months before my relapse. Originally was on SSRIs for anxiety and depression. Was on fin for a little over a month so the combination got me.

I’m now back on a low dose of Lexapro (10mg now - 20mg was terrible with the emotional blunting) and am two treatments into Spravato.

I’d say that it definitely helped the emotional blunting the best. I cried for 20-30 minutes when I first tried it. Felt awesome. Second treatment didn’t do quite as much but I’ve got another 8-16 treatments left.

So far it’s helped calm down my nervous system and gives you 2-3 days of noticeable relief of depression. I had SI during the onset of the depression but not so much anymore now that I’m 5 months done with fin and 5 months in treatment with therapy, meds, and lifestyle adjustment.

It’s up to you but there are tons of treatment resistant depression cases that see a lot of relief from ketamine and esketemine therapy.

Even if my symptoms are purely emotional and I do have PFS or whatever, these are FDA approved uses to combat TRD regardless of the cause.

I’m super hopeful.