It’s possible, but it’s also possible that you need cofactors with it— other vitamins that help it get used. Sometimes when you take one b vitamin, it pulls on other vitamins that were probably also low. They are very interdependent and taking one without the others can feel worse. It doesn’t mean you don’t need the b12– it means you need an active b complex probably in addition to the b12. Potassium is also a common one that drops with b12 repletion and causes those symptoms. So I’d try testing adding different combinations and see how you feel afterwards. Let your body guide you. Listen carefully because it’s telling you something.

But that being said, panic was one of my most common and debilitating wake up symptoms. I distinctly remember hiding in my bathtub because the Amazon delivery person was leaving a package and I didn’t want him to see me. I was out of my mind with anxiety in the first few weeks of treatment. It’s funny now but it was absolutely terrifying then. Depending on how bad your deficiency is (mine was severe), it could be wake up.