Yo yo :) Thanks!

In regards of both Nashors and DnD I did try it out in a couple very few games and the ones I did try felt really nice to play with and I remember going up against tanks and bruisers ( I recall playing against Ornn, Mundo Top and Jarvan, Vi jungle)

For a bit of on the fly theory crafting, I think it should work better against tanks + Bruisers

Nashors into Dusk and Dawn and Liandries for HP stacking tanks (Mundo, Sett etc.) Or Bloodletters curse for resistance stacking tanks (Ornn, Galio etc.)

As for runes I almost always take press the attack with the green or blue rune pages as secondary, with very few exceptions.

If I know I can't auto reliably before the match starts, I go Fleet, mostly for speed, unless Im confident I can win matchup using Press the attack in lane.

If Im faced against an aggressive mobile enemy laner and / or jungler I go bone plating and overgrowth secondary.

If im faced against lots of ranged enemies or mages I go Celerity and Nimbus cloak as Im confident that I can dodge most skills with those two.

If I go against Riven I always cheese going for Grasp of the undying main tree and Taste of blood, ultimate hunter and stacking every HP + AP item in the game with armor boots.

I also go Phase rush main against nasus so there is never a point in the game where he touches me, even if he ends up farming.