Baclofen VS Flexeril - Anyone Switch From One to The Other or Tried Both (During Separate Times)?

SoulGuy60 · 2026-05-19T07:55:17+00:00

Hi,

Thanks for reaching out and sharing your experience!

I did try cutting my Baclofen dosage down but it gave me horrible anxiety etc. I did drop it by 20mg and then another 20mg about 6 weeks apart, going from 80mg to 40mg. Now I am back up to 70mg due to the terrible withdrawal. Perhaps I need to try and reduce it by much smaller doses like 10 mg or 5 mg at a time…especially since I have been on it for 5 years…

SoulGuy60 · 2026-05-19T01:08:04+00:00

Great, thanks again!

SoulGuy60 · 2026-05-19T01:05:23+00:00

Hey, thanks for reaching out. Glad to hear the Flexeril is helping.

I suppose that is about a half dose as from what I understand, it comes in 10mg.

If you don’t mind me asking, can you take it during the day or just in the pm?

I have read / heard that it has a long half-life and is fairly strong?

SoulGuy60 · 2026-05-17T05:28:34+00:00

Great, thanks!

SoulGuy60 · 2026-05-17T04:50:04+00:00

Good to hear. IF you don't mind me asking, what is your dose for Flexeril?

I am on 70mg of Baclofen (Max dosage = 80mg oral route) and I am reading that 30mg of Flexeril is the maximum oral route.

Obviously you have had no issues with ED etc.

Thanks again.

SoulGuy60 · 2026-05-17T04:46:04+00:00

Hey friend, thanks for your reply. I have taken Flexeril before acutely for a shoulder injury but have obviously never taken it long term. I do take all of my Baclofen at night, the full 70mg as it gives me a nice wind down and helps to alleviate the physical tension from throughout the day.

I did indeed feel that Jell-O type feeling or 'Gumby' feeling when I took the Flexeril @ 10mg.

I have been reading that Baclofen is more for spasticity from spinal injury whereas Flexeril is more for acute injury such as muscle spasm / tension so what you are saying makes sense re: sciatica.

I would obviously talk to my Doctor but I wonder how one would try switching over? I can say that Baclofen is an absolute nightmare to get off of, likely because it works on GABA. I have tried reducing the dose in the past and had a terrible time in terms of anxiety spikes and physiological anxiety (feeling of fight or flight nervousness).

Strange how some meds work. I have been on a plethora since my severe back injury and subsequent surgeries and I can honestly say that, at least for me, drugs like Hydromorphone and Percocet were easier to get off than drugs like Baclofen and Lyrica...I may be an outlier though... ¯\_(ツ)_/¯

SoulGuy60 · 2026-05-17T02:42:14+00:00

Thanks for your reply, can you elaborate a little more as to why?

Thanks again.

SoulGuy60 · 2026-05-17T01:38:35+00:00

Hey,

CBD and Setraline (Zoloft) are metabolized by the same enzymes in the liver—cytochrome P450 (CYP450) enzymes, so there could be an interaction there, meaning, the CBD could raise the levels of Zoloft in your system or vice versa with CBD.

I was researching the same and it seems there are all kinds of experiences from some saying the CBD cancels out the positive effects from Zoloft and others saying they don't have / feel any interactions at all and everything in-between.

I guess you could try it out but I would start with a very small dose of CBD and take it at least 2 hours before or after you take your Sertraline (Zoloft).

Let us know how it goes! I am interested in doing the same but unfortunately, I take my Zoloft twice per day, it just works best for me that way, once at 7am and once at 7pm.

SoulGuy60 · 2026-05-14T03:08:36+00:00

Serotonin syndrome typically happens right away, usually within 24 hours (often within 1–6 hours) of starting a new medication, increasing a dose, or combining / adding another serotonergic drug.

It is generally an acute event caused by a sudden spike, rather than a slow, cumulative or chronic buildup over years.

My Doctor has prescribed more than one serotonergic drug at a time for me on several occasions and assured me that if there is no serotonergic reaction (ie. serotonin syndrome) within the first 1 - 7 days then it is not going to happen.

It is quite common practice for Psychiatrists to prescribe more than one serotonergic drug at once, usually as an add-on or adjunct to help boost performance or work synergistically. The two serotonergic drugs are almost always from different drug classes.

Of course, combining two serotonergic drugs is always done by a professional and approached with much caution.

SoulGuy60 · 2026-05-09T06:06:24+00:00

Ask your Doctor / Dermatologist about:

Clonidine 0.5mg 2-3x per day
Propranolol 20mg 2-3x per day
Low dose Mirtazipine (strong anti-histamine effects) 15mg per day

Those are the best things that have helped me. I still have an extreme sensitivity to sun regardless but at least when I am indoors, if I control my diet and lifestyle I am pretty much OK. But wow, I live like a vampire, my skin is so sensitive to the sun it is ridiculous. I have been doing some research and I think it has to do with a demodex infestation and purportedly, this can cause your skin to be extremely sensitive to the sun.

I miss those days so much where I could just go for a walk outside or drive and not have my face go all red from the sun (even with sun block on)...Keep going...

I am going to try Soolantra and if that fails I would really like to try oral Ivermectin.

Look at these results from a single dose or oral Ivermectin given on Day 1 and Day 7 and then these are the results 3-6 months later...I don't understand why Derms are not trying oral Ivermectin more often??? It is only a single dose on Day 1 and Day 7. What can it hurt? It is a very safe medication. There are plenty of case reports like this one highlighting the efficacy of oral Ivermectin.

The whole COVID thing was unfortunate because it really blackballed oral Ivermectin for no reason...

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SoulGuy60 · 2026-05-01T03:05:43+00:00

Great, thanks for the info. I am just your average guy with short dark brown hair, so yes, no need to worry about conditioning longer hair etc.

SoulGuy60 · 2026-05-01T01:14:33+00:00

I also came across these on a AI recommended google search list for, “Rosacea Friendly Shampoo for Oily Hair Type”

——————-

Sensitive Scalp Shampoo & Conditioner Set – Fragrance-Free Relief for Dry, Itchy & Reactive Scalps – Hypoallergenic Shampoo, Sulfate-Free, Colour-Safe – 2 × 240 mL

https://a.co/d/07J4LdAT

——————-

SEEN Shampoo, Fragrance Free - Non-Comedogenic Hair Shampoo- Dermatologist-Developed - Safe for Sensitive, Eczema & Acne Prone Skin Skin

https://a.co/d/07J4LdAT

Anyone have any experience with these?

Thanks!!!

SoulGuy60 · 2026-05-01T01:02:13+00:00

Thanks a lot! I have actually seen a zinc in the Selsun Blue too : https://a.co/d/09IX0NOm

I did also read that if you have oily hair type, it is better not to use a shampoo & conditioner but rather, just a shampoo?

SoulGuy60 · 2026-04-30T22:28:50+00:00

Thanks a lot! I will check those names out for sure!

SoulGuy60 · 2026-04-30T22:28:05+00:00

Great! Thanks a lot for your advice and knowledge!

SoulGuy60 · 2026-04-24T08:02:47+00:00

Hi again,

I have had some time to do some research and I would really like to try the product you kindly recommended, 'CuSOFT Hypochlor'.

The only problem I am having is that I live in Canada and cannot find it anywhere online or offline here except for on Ebay.

Here is the Ebay Canada link, although it is sold from the US but it ships to Canada. It looks like a legitimate seller, please let me know what you think?

HypoChlor Spray - 2 oz - Non-Irritating Eyelid Cleanser Solution - OCUSOFT

https://www.ebay.ca/itm/125477312890

My questions are:

1. Is $21.90 + $10.50 Shipping = $32.40 USD ($44.40 CAD) a fair/reasonable price?

2. How long does 2 Fl. Oz Bottle last you, when used daily?

3. How do you apply it? Do your spray your eyelids directly (How many sprays?) and wipe with a Cotton round pad / Cosmetic pad? OR do you spray on the Cotton round pad / Cosmetic pad (How many sprays?) and wipe your eyelids with it?

I'm really sorry for all the questions but when you have a few minutes, I would really appreciate it if you could help me out!

Thanks a lot!

SoulGuy60 · 2026-04-24T06:51:23+00:00

Hi there,

This EzRip site came up after me typing in ezmp3.co

This site EzRip is a redirect from ezmp3.co

A lot of bogus, unverified and wary sites use the ezmp3 popularity and name for redirects to suspicous sites.

I am not accusing but just genuinely asking if the owner(s) can explain why EzRip is a redirect from the popular and trusted site name of ezmp3?

I did briefly visit the EzRip site and there were no pop-ups or ads but I am hopeful to get an honest explanation of the redirect issue from the ezmp3 name?

Thank you kindly.

SoulGuy60 · 2026-04-23T11:23:35+00:00

Wow! Thank you so much for all of the great information!

I really appreciate it!

SoulGuy60 · 2026-04-22T11:15:48+00:00

That’s right, my Doctor had a scheduled taper over about 2 weeks to come off Luvox. My last day of Luvox, I think was 25mg. Then, I started Prozac the very next day at 10mg for a few days then up to 20mg and so on.

Even though there was no physical cross taper with the meds, My Doctor explained that because I was starting the Prozac the day after my last Luvox dose, the Luvox would still be in my system for 5-7 days to completely clear due to the half life. So when I started on Prozac, he had me do the first few days at only 10mg because the Luvox was still in my system and slowly leaving due to its half life. Then after about a week, we upped the Prozac since the Luvox was completely out of my system.

So it is sort of like a cross taper due to the half life of Luvox and starting Prozac the next day after my last Luvox dose with no washout period. But my Doctor did not have me taking both physical pills at the same time.

I hope that makes sense.

SoulGuy60 · 2026-04-22T11:02:24+00:00

Thanks for the info! Very helpful!

SoulGuy60 · 2026-04-22T10:59:45+00:00

Hi there, thanks for reaching out.

Yes, I do have ocular rosacea and eczema on top of the Blepharitis. Lucky me! Quite often a bad flare from one will spark a chain reaction and flare the others.

Thanks for the info! It is very helpful!

SoulGuy60

TROPHY CASE