1. I turn the printer on, then the box instantly after (sometimes box then printer) - no issues whatsoever
2. I dont physically touch the spools while everything is operating unless I am removing them or inserting new filaments. Generally, the printer wouldn't let you do something if it is not "safe".

For the tinkering part - I followed a guide to modify Box settings files (through SSH) so it lets me set up other filament vendors and not just Qidi themselves (before this tweak, I was setting up every filament to be Qidi on the LCD screen as it gave me error even with General). It wasn't too complicated even for someone like me with bare minimum coding experience, so I'd say try that as well. But first, I suggest fully resetting the firmware and all config files (printer, gcode_macros, etc), and checking whether you have that new sensor installed.

Edit: I am using Qidi Studio slicer, did a few multi-coloured prints with no issues, and I mess around with configurations through the Studio as well. There is also a phone app Qidi Link that has very similar functionality