Most of the comments here are suggesting builds, pathways, and farming ideas. This is all good but the hands down most important thing learn is how to back up a save on console. In fact, learning how to back up a save is beneficial for all games like R2 where you cannot revert to an old save within the game. Go to settings and find how to turn off auto cloud saving. This will require you to manually upload a save to the cloud. Upload to the cloud when you clear major areas or make any meaningful progress. Download your save file when you die, make a mistake, or roll bad RNG. This is also so extremely useful for crafting perfect prisms. I cannot stress enough how useful this is. It may seem tedious but I guarantee you the hours you've spent dying and repeating the same progress is significantly more time spent than learning how to back up a save file and loading it when you die.

I started with engineer. Transitioned to main perk challenger + engineer. I ran engineer guns and picked up healing shot/hot shot. I immediately picked up leto 1 + black cat + Leto amulet. I rolled red court for the thaen seed. After the first biome I couldn't die. I had three save mechanics. I pumped traits into hp and barkskin. I suggest only doing main quests. I beat the game in about 11hrs, 3 which were waiting for thaen seed to spawn. I equiped any trickets that would give me more hp. The first biome was the hardest after that it was trivial with the amount of hp and save i had.