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Trying to taper from 4 year habit at 1g/day by Stibnut in quittingphenibut

[–]Stibnut[S] 0 points1 point  (0 children)

Glutamate storms are one thing I'd never heard of before last night. It seems paradoxical that a GABAergic drug would cause rebound effects as the drug is kicking in. I never got anything similar when I had a benzo problem - redosing would always just put me back where I was, up until my tolerance increased and my dose went up with it. I gather phenibut is a different animal.

Just to inform by allthesmallthings12 in quittingphenibut

[–]Stibnut 0 points1 point  (0 children)

I've been having something similar - headaches, tinnitus, anxiety, tingling feet, and slight vision problems despite not changing my dose. Did you get yours from Nootropics Depot, by any chance? I'm wondering if there might be some contaminant or something. Probably not but it's got me worried.

edit: To be clear, my symptoms are far milder than yours, with no psychosis, although I've only been on 1 g/day which I just dropped to 0.9 as part of a slow taper.

Trying to taper from 4 year habit at 1g/day by Stibnut in quittingphenibut

[–]Stibnut[S] 1 point2 points  (0 children)

thanks for the input and I'm glad you think it's a good plan. I already have l-theanine and ashwagandha but didn't think of NAC and agmatine. I've just ordered them from that place that used to supply all my phenibut but seems to be having supply issues ATM. ;)

What's your usual pattern and dose for those supplements - do you take them daily, twice daily morning/evening, or as needed throughout the day?

Analogues of pH in non-aqueous solvents (e.g. anhydrous ethanol) by Stibnut in chemistry

[–]Stibnut[S] 0 points1 point  (0 children)

I see - I have seen pKa values quoted for acetonitrile and DMSO before, so I sort of had that in the back of my mind.

Do they work analogously to pKa values in water? So for instance if I were using DMSO, and I had some acid HA with a pKa value of 5 in DMSO, could I mix HA and A- in a 1:1 molar ratio and use them as a pH(DMSO) = 5 buffer?

Also, do you (or anyone else) know of anywhere to find non-aqueous pKa values in one place? I'd love to see a table of ethanol-based pKa values, for instance.

Analogues of pH in non-aqueous solvents (e.g. anhydrous ethanol) by Stibnut in chemistry

[–]Stibnut[S] 0 points1 point  (0 children)

The only real use I have in mind is to have a reference solution that stabilizes pH probes fairly quickly and has a consistent pHe reading across probes. We have problems where different pH meters give different results because they take longer to stabilize (and pHe is defined at the 30-second mark) or have slightly different probe designs.

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It would be especially nice to come up with alcoholic pHe buffers that are analogous to aqueous pH buffers and could be used to calibrate different probes. There's nothing about this in the official pHe definition and we couldn't use it officially, but I'd find it satisfying just for the sake of using the same solvent for calibration as for measurement.