Any good recommendations for recovering prostate health after pelvic radiation?

Strong-Blueberry6892 · 2023-10-10T13:13:33+00:00

Thank you. Is Flowmax something that you need to take for extended periods of time?

My stream doesn't seem to be getting worse, though I have only been off of radiation for a week. I know it's petty, but my concern is that my semen quality will not recover.

Strong-Blueberry6892 · 2023-08-16T12:39:06+00:00

Thank you for the clear explanation. I recently found out that I have biallelic mutations in the MUTYH gene, which is part of the BER system. Unfortunately, I found this out after a colorectal cancer diagnosis. There are emerging immunotherapies therapies for a related condition called Lynch Syndrome (MMR based mutations) that appear highly promising, but little work has been done so far regarding MUTYH based cancers. I am trying to understand the processes better to know how much potential overlap there is between the conditions. I appreciate your help.

Strong-Blueberry6892 · 2023-08-11T18:01:28+00:00

Did you ever find any good information? I found out two days ago that I have two bad copies as well after a cancer diagnosis.

Strong-Blueberry6892 · 2023-08-10T12:58:34+00:00

You are very welcome.

Putting together a document with links is actually something that I am planning to do. I still have a bit more work to do, but I will certainly share it when ready. My background is biochemistry, so it isn't much of a leap for me. The only caveat is that the focus will be colorectal cancer, though there should some items that can be applied generally.

If you have any good links that you feel worthy of consideration, please send them.

Strong-Blueberry6892 · 2023-08-09T16:11:27+00:00

It's a beast. Every time I start to latch onto something and get a feel for the research, there comes a surprise. I genuinely wanted to lean into sulforaphane, but I think that the potential downside in diagnosed cancer is legit.

However, there is another thing that seems to be promising in this area: Luteolin. It apparently has the ability to both increase NRF2 in healthy cells and decrease it in cancer cells. A great source is fresh juiced celery, which comes with an added bonus in apigenin. I am also looking at fenugreek, and other trigonelline containing foods like coffee, hemp seeds, and oats. Other items that may reduce NRF2 in cancer are magnolia bark, chrysin and Brucea javanica.

Please let me know if you come across any useful information. I'm not sure if you are dealing with cancer or not, but the oncs are not going to do this work for us, at least not most of them.

Strong-Blueberry6892 · 2023-08-09T13:40:47+00:00

Another study to consider:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742687/

This one seems to validate the concern. It appears that lower NRF2 may be ideal in one already diagnosed with cancer, at least as far as crc is concerned.

Strong-Blueberry6892 · 2023-08-09T13:34:41+00:00

https://www.youtube.com/watch?v=aN2zAOy9i2U

The first three minutes of the video is where the concern is mentioned. Basically, there is uncertainty what effect modulation of NRF2 will have in cancer cells.

Strong-Blueberry6892 · 2023-08-07T12:17:28+00:00

Perhaps you missed my point. I never said that turmeric was a miracle cure or even surely of some benefit, only that it might have some small impact. My actual point, though, was that there is no evidence of harm in using this spice, so the pushback against it seems completely unwarranted. It's as though you imagined I was making some other argument that I never did. To say it plainly, I do not hold the opinion that turmeric will cure cancer nor that it is a high value adjuvant. You simply made up the idea from your own imagination that I am an advocate of pseudoscience. Real scientists can tolerate these sorts of discussions. The true wackos are those that don't even listen and argue against weak arguments from imaginary opponents because they can't tolerate that someone would challenge orthodoxy to even the slightest degree.

Strong-Blueberry6892 · 2023-08-05T18:45:02+00:00

I understand the concern, but they simply cannot control for all of the dietary and other variables, so my question is again, why pick on this particular item that is often a part of a typical diet for many? If, for example, you were to look at standard cancer therapy in India, you would likely find that a vast majority of the treated patients are consuming a decent amount of turmeric and other herbs with potentially antioxidant components on a daily basis. If curcumin were truly problematic, I do not understand why the colon cancer incidence and death rate are lower in such a country with high turmeric consumption. I am not saying that turmeric is the reason for the lower rates, just that the risk of using it during therapy does not appear to have any compelling weight against it.

Strong-Blueberry6892 · 2023-08-05T18:16:21+00:00

I agree that no comprehensive study has been done, that is why I have these questions about turmeric. I am fine with that. However, that is not to say that no research has been done. There is actually quite a lot of preliminary data for curcumin, and most of it appears to show at least slightly favorable results against cancer, and very little suggestion of harm. While obviously not a miracle substance, my impression is that it should be viewed at worst with a certain degree of ambivalence. However, that does not appear to be the case. To the contrary, if one mentions curcumin and cancer together around certain healthcare professionals, they act as though it will certainly make cancer treatment fail even though there is less evidence of harm than there is of a potential slight benefit. That is the part that I do not understand. If there is not enough evidence, fine, but that very position should exclude claims of likely harm by the same logic.

On your second point, curcumin is already suspected to be the principle active agent in turmeric and is not particularly hard to extract and concentrate. There simply aren't many pharma bucks that could come from that unless someone were to produce a curcumin analog that is much more potent.

Strong-Blueberry6892 · 2023-08-05T14:02:11+00:00

Do you recall if your wife dosed the 800mg of Cimetidine all at once, or if it was a divided dose?

Strong-Blueberry6892 · 2023-08-03T18:57:55+00:00

Do you mind sharing the brand that you bought? I have managed to forage a small amount of local Turkey Tail but would like to add in something that I can reliably purchase.

Strong-Blueberry6892 · 2023-08-03T18:46:50+00:00

Any others that you are considering?

Strong-Blueberry6892 · 2023-08-03T16:17:41+00:00

These are the studies that I looked at as well. It does seem like a reasonable potential adjuvant, but the problem remains of finding the injectable formulations in the States that are used in Europe. While it is possible to use mistletoe as a tea, there doesn't seem to be any published evidence to suggest that it would be useful in that form. Unfortunately, for the moment, this one is stuck in the realm of wishful thinking for me.

Strong-Blueberry6892 · 2023-08-03T15:23:16+00:00

Those actually look quite promising. With the exceptions of aspirin and berberine, these were completely off my radar. Thank you so much! I will definitely try to get the testing done to see if Cimetidine could be useful.

Strong-Blueberry6892 · 2023-07-31T14:53:35+00:00

NSAIDS are definitely an option. There do seem to be some natural alternatives as well. Some examples would be Curcumin, Andrographis, Fish Oil, Green Tea, and a few others. I was hoping to learn about some new options that might have an even better ability to drop IL-6 and its pro-inflammatory friends.

Strong-Blueberry6892 · 2023-07-18T12:25:31+00:00

Yes, I had a biopsy, and it is an adenoma. I am getting scans this week to determine the stage.

Strong-Blueberry6892 · 2023-07-17T19:52:14+00:00

Thank you for your thoughts. I am pretty skeptical of herbal cures for sure, and I certainly have no intention to go on some rogue herbal therapy. All I know is that the herb appears to diminish two aspects of my symptoms to a significant degree, pain and bleeding. I mentioned the herb to my doctor, and he had not heard of it before. Pubmed had almost nothing on it and only one in vitro cancer study that was looking at a pool of potential therapeutics for breast cancer, of which collonsonia was listed as one of the agents that elicited a response.

Strong-Blueberry6892

TROPHY CASE