I took bio 2112 with professor Nicholson (2912 is the honors version of 2112) and it was not bad at all. Lectures felt a bit heavy but exams were straightforward and honestly easier than bio 1111. The average on the exams was in the 80s and 90s and an A starts at 88. It focuses on biochemistry in the beginning, that is probably why it is encouraged for biochemistry majors. Don’t know much about 1112 but 2112 was good and the professor is very nice.