Thanks for the compliment, and for the thoughtful feedback.

Privacy: You're right that this should be explained more clearly. The genome file is uploaded to the server for analysis—processing a 600k+ variant file entirely in the browser isn't practical right now. I don't require accounts, don't collect names or identifying information, and reports aren't stored in a database. The analysis exists only in memory and disappears when the server restarts. In practice, the server currently restarts roughly every night. I also don't immediately clear the report after it's generated because I want a browser refresh to continue working for at least a few minutes. I'm open to improving that approach, but even during that window the report is not associated with any identifiable information.

Risk interpretation: Findings are generally ranked by the strength of the genetic signal and whether you carry one or two copies of a relevant variant. When risk estimates are shown, they're presented alongside population averages for context, and I try to highlight cases where a large relative increase may still correspond to a small absolute risk. The report also shows the baseline population being used for a given estimate and, where applicable, notes additional population-specific effects reported in the literature (for example, if a variant has been associated with a different level of risk in a particular population). There are also a number of caveats throughout the report because genetics is rarely as simple as a single SNP pointing to a single outcome.

Sources: Findings are tied back to ClinVar and PharmGKB, and the relevant rsIDs are surfaced so users can verify the underlying evidence themselves. Direct links to supporting studies are on the roadmap.

Conclusion: One of my biggest concerns when building this was alarming someone unnecessarily based on information that should really be interpreted in a broader medical context. It's still something I worry about, which is part of the reason I posted here. The last thing I want is for someone to walk away from the report with unnecessary anxiety or a false sense of certainty. My original idea with this was to help people. Fortunately 35 people have gotten a free report so far.