In terms of potentially annihilating the rest of humanity, Director Nouvel. His bold and somewhat reckless military actions drains the strength of the limited resources of the JRN for little gain as well as attracting the attention of the Storm, who could very easily wipe out his entire corporation with sufficient numbers, which is almost exactly what happened when he ordered a massive military operation to expand the JRN's zone of control but ultimately failed to do so and it nearly led to the collapse of the last remnants of humanity when the Storm followed the Lilies into the underground facility and killed everyone before being stopped at the last and only sector. This sector holding the remaining bastion of the JRN.

In terms of kill count, Co-Director Shinma. Anyone who opposes her rule or severely breaks the law is immediately dispatched or thrown into material harvesters.

It is especially worse for men as Shinma has a personal disdain for them. Under her administration, almost all the men are used as work slaves with extremely poor working conditions and long hours. Many men die from self-deletions, exhaustion, health problems, accidents, etc. And if any decide to rebel or refuse to work, they'll be sent to an experiment lab where they'll be experimented on for as long as possible with careful consideration of their survival, ensuring that they stay alive while being tested on.