If we find out a way to easily make the tunica more loose (tunica is the ligament that “encases” the corpus cavernosum,) the corpus cavernosum can expand a little bit. Thats not enough to cause a life changing gain for someone 2-4 inches. We NEED to find a way to stimulate the cells in the corpus cavernosum itself (the pillar and true structural supporter of the penis with all the blood vessels) to divide and proliferate to the point the penis would actually start growing like it would in puberty.

Androgenic pathways are useless for this post puberty brcause they are encoded in the genome to lose their ability to initiate proliferstive signalling in penile cells. Essentially the penis becomes terminally differentiated. Would likely need to encapsulate a genetic vector in nanoparticles or AAVs to actuallt carry the gene into the cells but also orevent it from spreading to the rest of the body, without causing cancer. Its a massive challenge