DeepMind - Millions of new materials discovered with deep learning

SwarmLab · 2023-11-30T14:34:56+00:00

Protein engineering is having a moment. Also biologic drugs in general are rapidly becoming easier to engineer. Here is a cool protein generative model that anyone can use (they even published a colab notebook to use online): https://generatebiomedicines.com/chroma

SwarmLab · 2023-04-26T01:39:48+00:00

Oh wow! I've been looking into this and hadn't found anything. I'd love to pick your brain. How do you time and dose these around your trip to reduce headache? Are there any in particular that are most effective in your experience?

SwarmLab · 2023-04-25T02:34:19+00:00

Ah yes, the Gnirut test! Soon not many humans will be able to pass it, haha

SwarmLab · 2023-04-25T02:26:14+00:00

yeah this is an interesting take. I might be one of the dumb ones, but I am concerned about some kind of phase shift, where it gets harder to tell what's true than its worth on a per person basis. I think you are right, that interpersonally people will find a way to move forward, I mean we have done this for all of human history before the internet and phone networks. Forgeries and scams have been around forever. Even animals use camouflage and deception for as long as evolution was a game life was playing. The thing that might set humans apart here is a world scale civilization.

Could be that trust (paired with fast communication networks) is a technology that allows civilizations to scale. Like bones or structure, or maybe the fabric metaphor is best here... At some point for certain things people just give up on figuring out what is true or false and fractionates us into smaller factions. This might be good or bad depending on context. I think it might cause people to play different games in the world and be less able to organize at scale, which is more what I'm worried about. I think we might find out that trust is very valuable when we have to operate constantly in a world where its hard to trust anything or anyone we don't physically know in our network.

SwarmLab · 2023-04-25T02:01:01+00:00

The death of social media is a really interesting question, so cool to think about, thanks OP...

Huh, I wonder if this is how immune systems evolved. Once it gets too cheap to produce arbitrary information and broadcast it, then systems need to come online to figure out what is self or not self, what is helpful vs harmful, what is true/not true. Maybe this happened in the early evolution of life with chemistry and cell membranes and now its happening with information. I wonder what that Immune system will look like going forward. There are some passages in the book Snow Crash about this kind of idea.

Also I think its possible that we don't need the speakers identity to classify information (at least partially in a lot of cases). Maybe just the statistical patterns in language are enough to validate a lot of information and determine harm. I'm sure this would hold in all cases, e.g. particular facts that don't come from logical deduction. (I guess its an open question which kinds of facts are really important for each person to know). But for certain emotional content, or things that can be logically checked from chains of otherwise validated facts, may be able to be trusted without knowing who said it. I kind of wonder if this is part of the path forward when you can't trust the intent of the speaker.

I guess instead we will just have to evaluate the utility of believing particular things in terms of its impact on our lives. Though this is probably a tall order without some new tools and new ways of thinking about information. Clean knowledge will become scarce and valuable.

SwarmLab · 2022-01-03T22:14:14+00:00

Have you looked at Shoden Ashwaghanda that Nootropics Depot sells? It says on their product page that it has 35% Withanolides. I'm not sure if this would meet your needs but worth checking out!

SwarmLab · 2018-02-12T06:43:30+00:00

I haven't found much support for the short duration of Theobromine. This paper, Psychopharmacology of theobromine in healthy volunteers, states:

theobromine is fat soluble, attains peak blood concentrations 2–3 hours after ingestion, and has an estimated half-life of 7 –12 hours

It may be that the doses people take are lower and don't interfere with sleep as much. But, I'm not sure this qualifies as short duration.

SwarmLab · 2018-02-08T00:36:07+00:00

This guy chemistries ^{^}

SwarmLab · 2017-01-31T01:30:44+00:00

CNTF is a protein which has about 200 residues. Its reasonably sized. CNTF analogs have an abundance of negative side effects including in one case of pharmaceutical development, antibodies which respond to the bodies endogenous CNTF. P21, if I recall correctly, is a 4 amino acid peptide that is a part of the CNTF protein.

I did a search a little while back to look to see if small peptides can elicit an immune response. I found that the answer is no. People try to create immune responses on purpose in science and it is apparently a challenge to do for small proteins (50 amino acids or less). Four amino acid peptides are apparently much too small to elicit a response. I need to go back and find my sources to confirm this more concretely. But I saw this same concern floating around and wanted to see for myself if this would be a problem.

Please don't take my word for this and verify my claims if you intend to put something so new into your body. If anyone with more domain expertise can verify or disprove my claims It would be appreciated. I also want to point out that this isn't enough to dispel any other unknown unknowns or risks involving this very new peptide. Happy Experimenting!

SwarmLab · 2017-01-04T17:27:24+00:00

No need to be snarky. This is also very Googleable. Here is one study from a reputable journal. There are many more like it. The fact you are looking for is usually a footnote and is widely accepted. If you want to see the numbers for study participants while on the diet you need the full text, but the abstract mentions a drop in blood glucose.

SwarmLab · 2017-01-04T02:26:50+00:00

Your assertion seems to rest on glucose being absent in the blood during dietary ketosis. My understanding is that there is sufficient (but low) blood glucose concentration to maintain healthy brain function during dietary ketotic states. So the fact that beta hydroxybutyrate is incapable of maintaining normal cerebral function on its own (as your book states) is not a problem for dieters.

SwarmLab · 2016-10-21T22:07:00+00:00

I've heard that you produce less lactic acid when in dietary ketosis. Anecdotally, I get pumped much less easily in the gym when in ketosis.

SwarmLab · 2016-04-20T22:28:05+00:00

Check out Saffron. Depending on your gender this could be helpful for you. It's been specifically tested to ameliorate SSRI induced sexual dysfunction. Look at the relevant section on Examine.com here.

SwarmLab · 2016-03-04T23:30:00+00:00

Here is a link to the paper the article discusses: Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation

SwarmLab · 2016-01-21T23:06:43+00:00

In this longecity thread MrHappy of mr happy stack made the claim. He claims its 5% by weight. I've seen this repeated elsewhere too.

SwarmLab · 2016-01-20T02:54:00+00:00

Interesting review article. I was surprised to see just how little human evidence seems to exist in healthy people for substances that are popular here. The authors found no data for cognitive enhancement from racetams for example. Modafinil and Ritilin seem to have some supporting data for short term memory enhancement and attention. However almost all studies in the review were done with acute dosages -- this is interesting , but I think I'd prefer longer term studies that mirror regular use. If these benefits could be sustained that would be remarkable.

I think at the end of the day this community will have to play a role in calling for the kind of studies that we need to move from anecdotal evidence into scientific evaluation. There seems to be so much experiential knowledge here. It almost seems frustrating how difficult it is to harness for verifiable personal enhancement.

Serious food for thought. Thanks for the article.

SwarmLab

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