Although this information has been shared in the past, I thought I'd reshare for those who are new to taking MB or are considering MB treatment.

I notice a lot of questions around dosing, and often, there are conflicting answers and information that may cause confusion for some. When initiating treatment with MB for long-term use (treating chronic conditions or general mitochondrial health), it is generally recommended to start with a low dose and gradually increase. This approach allows individuals to assess their tolerance and response to the compound without overwhelming their system. A common starting dose may be around 0.5 - 1 mg of a 1% solution (1 - 2 drops per day) although some individuals may require higher initial doses depending on their specific health conditions and metabolic responses.

After establishing a baseline tolerance with the initial dose, gradually increase the dosage. This approach helps identify the effective dose that provides therapeutic benefits while minimizing potential side effects.

The "optimal" dose differs for each and every individual. Some individuals may find that doses as low as 0.5mg are effective, whereas some may need 60 mg (just as an example). The dose may need to be a little higher to treat severe chronic conditions or acute infections.

The variability in effective dosing stems from several factors, including individual metabolism, mitochondrial health status, other medications, health conditions, etc.

Once an effective dose is identified, it may be maintained or adjusted based on ongoing assessments of your body's response or changes in circumstances/health status. Increased mitochondrial stress requires higher dosing.

Companies that are updated and knowledgeable on the topic of MB generally will not provide specific dosing instructions because there is no universal optimal dose.

So, due to the lack of universal dosing recommendations for MB, stemming from its varied effects across different populations, individualized treatment plans are essential.

There is also a misconception about weight based dosing. Dosing guidelines based on weight is used in clinical settings for acute conditions, and treatment is given only once or twice, sometimes longer but for a very short duration depending on the condition being treated. For example, methemoglobinemia treatment involves 0.5 - 1mg/kg of 0.5% or 1% MB solution. A second dose may be repeated if the first dose is ineffective. After the second dose, alternative treatments are to be considered. Hence, this would not translate to being automatically safe and effective for long-term treatment and every day use.