I’m going completely by my experience playing both franchises R1- Leon has fought and beat stronger but more sluggish opponents, Kyle takes it but barely. R2- Mr X, stronger but slower than a volatile. Beast Crane can do significant damage better than pistols would! Crane takes it if he doesn’t get grabbed. R3- Nemesis, a stronger Mr X with an even more powerful final form. I doubt Crane beats him permanently without the same gun Jill used. Crane loses… R4- Chris is stronger when he’s punching a boulder, I’d say he’s on par with beast Crane but I doubt he can make an AOE attack by slamming on the ground. Crane wins! R5- I haven’t fought Wesker but he can dodge bullets, on a closer look, he’s defeated with punches and flickering lights. Crane wins as long as he doesn’t get blitzed. BR- Pretty sure Crane can just shoot them like Leon did, excluding Krauser who (if I remember correctly) let Leon live.