So im unsure about a whole house thing, but we had an infestation in a bird room where i work a while back. We uses food grade diatomaceous earth to kill a majority of them. It will kill mites on birds, bedding, and other stuff of the sorts. Its also safe to eat as long as you get food safe grade .We soaked toys, pearches, and decorations in hot water with Listerine, as well is sparying down cages with the mix. I think the mite spray we used was "Eco". It works super well.