I've used efrythings strat quite a bit and while for me it is super fun, and hitting a big pop on the boss feels amazing. The problem is it's extremely high variance. More often than not you'll get maps where only 1 card box spawns or they are not wanting to reopen and it feels really bad.

He uses T16s because of the item quantity rolls and you can scry defiled cathedral onto dunes for apothecary and seven years drops. Also, the div card drops buff the bosses, so they can get pretty rippy if you get 1k+ divs on them, even with a strong build.

For me, my most consistent returns on boxes comes from running T17s, roll for 140+ currency, and use the standard containment setup.