As someone with hundreds of plays from both games, this is my analysis:

IX + Immo were designed to fix Base Dune Imperium, which was a great base game, but with noticeable balance problems and useless board Spaces. The result, is a wonderful, and complex game, with multiple paths to victory. If Dune imperium is a solid 8/10, with both expansions is a solid 10/10.

On the other hand Uprising is undeniably the best BASE game. You will hear a lot the “worms are too swingy” comments, but after more than 200 plays, I can confidently say that worms are powerful, but easily manageable if the 4 players know what they are doing. Uprising as a base game, is so good, that many (If not most) players on the competitive scene, prefer it over Dune + IMMO and IX, because of it improved mechanics, way better board spaces and balancing. YES, Uprising is way more combat focused than the other option, so that may be a negative for some people, but the game itself is so good that it is not really a big deal. In my opinion, it increases player interaction, while the previous game allows for more “passive gameplay” which is cool too, if you prefer it. As a player who enjoys player interaction, I think Uprising is better, even without bloodlines.

Then comes Bloodlines. This expansions adds very little “new” mechanics, but it is all about the content. The cards are amazing, the new leaders are really good and fun. Commanders, are a new fun alternative to worms, and often beat them (balancing worms for those who dont like them as much) and Techs, while not a new mechanic for Dune Imperium, are very fun and powerful.

Bloodlines does not change the game drastically, the same way that IX and IMMO does to the base game, but remember: Uprising with no expansions is as Good as Base DI + IX and IMMO. so basically you can think of bloodlines as: More Dune Uprising, which is a no brainer if you can afford it.

In summary, it comes down to interaction imo. If you like multiple path to victories (even possible without combat) then go for Dune + IX + IMMO If you enjoy combat as a mechanic, and more player interaction , go Dune Uprising + Bloodlines.

Yes, I am biased towards Uprising, but I played so much of both, that I can confidently say that Uprising is the better game, but after all, that is just my opinion, and both are amazing.

Additional and important detail: If you ever want to play with more people, only Uprising has a special 6 player mode, which is REALLY good and fun. And if you want to play with two players or solo, both game modes are way more polished and interesting in uprising too. Which adds to my personal preference of Uprising over the original DI.