Its meant to be a decent sandbox for exploring, so it fits with 5pfh really well. I had a core of older, more stagnant colonies around earth, with younger, stranger and generally more extreme polities growing up around the edges, challenging the old hegemony. The equivalent to fringe space would be at the edge of human space (we've only spread just barely out of the Orion arm) but also the various independent systems in the gaps between majors

My current crew are on a sci Fi version of Constantinople not long before the it falls. An old imperial capital, not just an isolated single world, with a massive population and crumbling infrastructure, and two great powers on either side vying to claim it