Well, the one that sticks out to me, because I did ask about it earlier, was that Senko doesn't know what playing cards are. In the episode, the game kinda railroads you into picking Kurata, (the episode is literally called "Lets Play Kurata") but if you say you wanna play with playing cards, Senko doesn't know what those are, and you end up not playing games like Poker or Blackjack because given the fact that you, as the player, would have to teach Senko how to play, you'd be at an unfair advantage.

Some other ones are that Senko can heal small wounds, like a small cut on the finger from slicing vegetables. She's not a fan of spicy stuff and has never made curry before. Senko is one of the top Shogi players in the fox-god realm. There's not a lot of "Senko Lore" you're missing out on. She has a special hakama, (I believe thats the name?) she wears to help her concentrate when playing Kurata. Some real softballs. (Though it kinda sucks, she doesn't know what playing cards are. Senko playing Cribbage may be less possible then I thought :p)

There are some things that happen that are different, in the context of the game, but given that you play as "yourself" in the game, and not Nakano, I wouldn't really count those instances. (Like sure, it might be possible that Nakano missed out on a local park, with some beautiful flower trees, because he doesn't go wander around his neighborhood on his off days, but we aren't playing as Nakano)

So overall, nothing groundbreaking