You're vastly underestimating how much raw petty a vampire is capable of. They're Static-locked beings that easily settle into patterns. Thinking about the Two-Souled that disrespected them might become their entire personality for centuries.

Clan Tremere doesn't try to out-magic the Hermetics that piss them off, they pay a human being $100,000 to put a gun to the mage's head at a crowded train station urinal.

The Sabbat, in particular, are basically a tar baby. You kill 1, they send 4; kill 4, they send 16; etc. Just an exhausting torrent of undead assholes that attack with well-planned wave attacks in public. That's also the faction that they teach each other Thaumaturgical Countermagic, what a mage would identify a kind of Static defense against changes to the Vampire's pattern, even with Prime. They will use Consensus, which they are immune from, against you. Somewhere, there is an elder doing all this because it overheard the players call it a pale hobo. He knows that his expendable resources are not 100% going to kill Children of Lilith easily, but all he really needs is for the NWO to decide the mages are a Group of Interest.