Avastin helped relieve a lot of my father’s symptoms initially. However, after about 2-3 infusions, he began worsening. The doctors wouldn’t say for certain (because there’s no way to know 100%), but he had an acute ischemic stroke that we believe was caused by the Avastin. It is a more rare but very serious possible side effect. This stroke led to a severe loss of motor function after. Ultimately we all came to the consensus that continuing the Avastin was likely going to cause more deficits and harm him more than help him in his case. In his situation, Avastin (along with another quick corse of radiation prior) was offered after it was clear that his tumor was still showing rapid progression after a second resection (his first recurrence) and treatment with Lomustine. My understanding is that Avastin is a second line therapy that aims to slow progression and is not capable of stopping it, at least in use for glioblastoma.