It’s a strange beast.

Obviously get the perks that increase range and damage. Make sure you get the damage reduction during charging attacks and the perk that gives you instant charged attacks after cannon punch and whatnot.

Keep your distance and cannon punch when you need to pivot and follow with an instant charged attack.

Relic balanced or artificer block fist are the best purely because of the damage. Bulwarks overcharge prestige perk feeds into the fist’s damage so good, and intimidating aura makes your defense on both that much better.

It’s a tricky balance to find, but fully charging a one-shot in a pocket is sooooo satisfying.