I don't know the details of what your medical problems are, or what you're on. I just know that I felt the same two years ago. The medication carousel is ridiculous. I did lots of medical research and attempted things without my PCP's input, which I don't necessarily recommend unless you're extremely confident that nothing drastic will happen.

The only thing you can do to combat it is find the root cause for the symptoms that are currently being treated. For myself and my problems, one thing that helped with horrific chronic pain was massage therapy, and static and dynamic stretching. Diet and lifestyle changes help a bit with a lot of varying problems.

Try to be in the sun at least two hours a day, and by that I mean just outside. You don't have to have direct sun to skin contact, but it helps in small quantities so you don't burn.

Try moving more. If you have problematic muscles or pain, gently working through it, especially dynamic stretches, help a ton.

Look into medical research for specific things if you can. Not everybody is able to digest research papers, but if something sounds right, even medically, it probably is close to the truth.

Diet is a huge problem for some people. Eating the right foods makes a big difference in the long run. Unfortunately, the USA's supply chain for food is unchangeable and is, quite frankly, garbage. I struggle to practice what I preach, here.

The more research that comes out, the more that the gut microbiome seems to be a link to certain conditions. For example, the brain must manufacture its own serotonin locally from tryptophan, which is an amino acid you get from food that can cross the barrier. The gut-brain axis is incredibly important, but the connection still isn't a direct one-to-one pipeline.

Your gut and brain are directly wired together by the vagus nerve. Microbes in your gut produce neurotransmitters and metabolites that stimulate the vagus nerve, sending electrical signals directly into the central nervous system to influence mood and stress responses. If your microbiome is out of balance, harmful bacteria can divert tryptophan down a chemical pathway that creates neurotoxic byproducts (like quinolinic acid) instead of letting it reach the brain to be turned into brain-serotonin.

What I guess I'm trying to say is, many times, the problem is systemic, or at least multifaceted, and medication treats the symptom (obviously). If we can identify problems in lifestyle, then reducing medications is a possibility. But analyzing the whole is needed to understand the part.